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Mechanism of gating and partial agonist action in the glycine receptor

Cell(2021)10.1016/j.cell.2021.01.026Source: DataRank Database

Mechanism of gating and partial agonist action in the glycine receptor is a research paper published in Cell (2021). On theSindex it has a DataRank of 0. It has been cited 155 times.

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Open Access155 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

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Enrichment:Funding (10 grants)Impact (FWCI 8.29)OA: greenTopics (82)IDs (PubMed, PMC, OpenAlex)Annotations (3)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (8)

Hongtao Zhu ORCID,Remigijus Lapė ORCID,Timo Greiner ORCID,Juan Du ORCID,Wei Lü ORCID

Live enrichment

PubMed:33567265 PMC:PMC8115384 OpenAlex:https://openalex.org/W3126984074

Medical Research Council

Grant: MR/R009074/1

Single molecule quantification of the activation, biophysics and pharmacology of GlyREM, a new structural model for pentameric ligand-gated channels

NIGMS NIH HHS

Grant: U54 GM087519

NIGMS NIH HHS

Grant: P41 GM104601

NIGMS NIH HHS

Grant: R01 GM100400

NIGMS NIH HHS

Grant: R01 GM123455

National Institutes of Health

Grant: 3R01GM100400-06S1

Structural biology of neurotransmitter ion channels

National Institutes of Health

Medical Research Council

Howard Hughes Medical Institute

FWCI

8.29

Citation Percentile

1.0%

Citation Trend

2020

2021

2022

2023

2024

2025

2026

greenLicense: Elsevier Non-Commercial

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/8115384

publisherhttps://api.elsevier.com/content/article/PII:S0092867421000696?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S0092867421000696?httpAccept=text/plain

journalhttps://doi.org/10.1016/j.cell.2021.01.026

Fields of Study

Nicotinic Acetylcholine Receptors StudyIon channel regulation and functionReceptor Mechanisms and Signaling0301 basic medicine03 medical and health sciencesAnimalsBinding SitesCell LineCryoelectron MicroscopyGlycineHEK293 CellsHumansImaging, Three-DimensionalIon Channel GatingMaleatesModels, MolecularMutant ProteinsMutationNeurotransmitter AgentsProtein DomainsReceptors, GlycineStyreneZebrafishgamma-Aminobutyric Acid

MeSH Terms

Protein DomainsAnimalsBinding SitesCell Linegamma-Aminobutyric AcidGlycineHumansMaleatesModels, MolecularMutationZebrafishIon Channel GatingReceptors, GlycineNeurotransmitter AgentsStyreneCryoelectron MicroscopyImaging, Three-DimensionalMutant ProteinsHEK293 Cells

Keywords

Partial agonistAgonistBiologyBiophysicsGlycine receptorReceptorNeurotransmitter receptorIntrinsic activityNeurotransmitterIon channelLigand-gated ion channelSignal transductionBiochemistryCell biologyGlycineAmino acidSMALigand-gated Ion ChannelsGating MechanismCryo-emPartial Agonists ActionModels, MolecularCell LineImaging, Three-DimensionalReceptors, GlycineProtein DomainsAnimalsHumansStyreneZebrafishgamma-Aminobutyric AcidNeurotransmitter AgentsBinding SitesCryoelectron MicroscopyMaleatesHEK293 CellsMutationMutant ProteinsIon Channel Gating

Sustainable Development Goals

SDG 3: 3. Good health

Mechanism of gating and partial agonist action in the glycine receptor

FAIR Checklist

Authors (8)

Funding (10 grants)

Impact

Open Access

Topics

Annotations (Europe PMC)