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The PP2A-Integrator-CDK9 axis fine-tunes transcription and can be targeted therapeutically in cancer

Cell(2021)10.1016/j.cell.2021.04.022Source: DataRank Database

The PP2A-Integrator-CDK9 axis fine-tunes transcription and can be targeted therapeutically in cancer is a research paper published in Cell (2021). On theSindex it has a DataRank of 0. It has been cited 222 times.

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0DataRank · unranked

Scored on demand from live citation data

Open Access222 citations

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Linked data & code

geo cellosaurus gen hpa pxd doi

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (9 grants)Impact (FWCI 13.55)OA: bronzeTopics (55)IDs (PubMed, PMC, OpenAlex)Annotations (6)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (33)

Sarah A. Welsh ORCID,Jennifer R. Devlin ORCID,Elisa Barbieri ORCID,Deborah A. Knight,Sarah Offley ORCID

Live enrichment

PubMed:34004147 PMC:PMC8567840 OpenAlex:https://openalex.org/W3162185013

NHLBI NIH HHS

Grant: R01 HL141326

NIGMS NIH HHS

Grant: T32 GM071339

Dutch Research Council (NWO)

Grant: 019.161LW.017

NCI NIH HHS

Grant: P30 CA010815

NIGMS NIH HHS

Grant: T32 GM133398

NCI NIH HHS

Grant: T32 CA009171

American Cancer Society

National Institutes of Health

National Health and Medical Research Council

FWCI

13.55

Citation Percentile

1.0%

Influential Citations

Citation Trend

2021

2022

2023

2024

2025

2026

bronzeLicense: http://www.elsevier.com/open-access/userlicense/1.0/

journalhttp://www.cell.com/article/S009286742100502X/pdf

BRONZEhttp://www.cell.com/article/S009286742100502X/pdf

publisherhttp://www.cell.com/article/S009286742100502X/pdf

publisherhttps://api.elsevier.com/content/article/PII:S009286742100502X?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S009286742100502X?httpAccept=text/plain

Fields of Study

RNA modifications and cancerCancer-related Molecular PathwaysUbiquitin and proteasome pathwaysMedicineBiology

MeSH Terms

AnimalsHumansNeoplasmsPhosphorylationProtein BindingRNA Polymerase IISubstrate SpecificityTranscription, GeneticGene Expression Regulation, NeoplasticRNA-Binding ProteinsMice, Inbred NODDrug Resistance, NeoplasmTumor Suppressor ProteinsCyclin-Dependent Kinase 9Cell Line, TumorMiceProtein Phosphatase 2Molecular Targeted Therapy

Keywords

RNA polymerase IIBiologyProtein phosphatase 2Cyclin-dependent kinaseTranscription (linguistics)Cell biologyCyclin-dependent kinase 9KinaseCancer researchTranscription factorBRD4PhosphataseMolecular biologyGene expressionCell cyclePhosphorylationProtein kinase ACyclin-dependent kinase 2PromoterGeneBiochemistryBromodomainHistoneCancerCDK9CTDIntegratorPp2aTranscriptional ElongationPause-releaseCrispr-cas9 ScreenPp2a Activation

Sustainable Development Goals

SDG 0: Good health and well-being