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NNT mediates redox-dependent pigmentation via a UVB- and MITF-independent mechanism

Cell(2021)10.1016/j.cell.2021.06.022Source: DataRank Database

NNT mediates redox-dependent pigmentation via a UVB- and MITF-independent mechanism is a research paper published in Cell (2021). On theSindex it has a DataRank of 0. It has been cited 73 times.

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Open Access73 citations

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Enrichment:Funding (24 grants)Impact (FWCI 4.97)OA: bronzeTopics (94)IDs (PubMed, PMC, OpenAlex)Annotations (3)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (53)

Inbal Rachmin,Kaustubh Adhikari ORCID,Luba M. Pardo ORCID,Ju Hee Lee ORCID,Alicia M. McConnell ORCID

Live enrichment

PubMed:34233163 PMC:PMC8349839 OpenAlex:https://openalex.org/W3182612754

NIEHS NIH HHS

Grant: P30 ES013508

NCI NIH HHS

Grant: R01 CA103846

Biotechnology and Biological Sciences Research Council

Grant: BB/I021213/1

The genetics of human physical appearance

NCATS NIH HHS

Grant: UL1 TR002541

NCI NIH HHS

Grant: R01 CA222871

NIDDK NIH HHS

Grant: P30 DK043351

NIAMS NIH HHS

Grant: R01 AR072304

NIAMS NIH HHS

Grant: R01 AR076241

NCI NIH HHS

Grant: P01 CA163222

NHLBI NIH HHS

Grant: P01 HL142494

NIAMS NIH HHS

Grant: R01 AR043369

NCI NIH HHS

Grant: R00 CA218870

NIDDK NIH HHS

Grant: P30 DK057521

NIGMS NIH HHS

Grant: R35 GM134957

NIAMS NIH HHS

Grant: T32 AR007098

Swiss National Science Foundation

Grant: 199252

Defining molecular mechanisms of mitochondria membrane remodelling by in situ cryo-electron tomography

National Institutes of Health

Grant: 1R01AR076241-01A1

Genetic and molecular basis for variation in human skin pigmentation

National Institutes of Health

Grant: 5R01AR072304-04

Preclinical models and therapeutic strategies for treatment of giant congenital melanocytic nevi

National Institutes of Health

Grant: 1R01CA222871-01

A druggable dependency in low-MITF/high-AXL melanoma: preclinical efficacy and mechanism of action in a key treatment-resistant subclass.

National Institutes of Health

Grant: 5P01CA163222-08

Targetable epigenetic and transcriptional mechanisms in melanoma that shape the microenvironment

National Institutes of Health

Grant: 5P01HL142494-02

Hematopoiesis in cardiovascular disease

Swiss National Science Foundation

Grant: 154461

The Time- and Spatially Resolved Aggregation of a-Synuclein and its Relationship to Cell-Cell Transmissibility

National Institutes of Health

Grant: 5R01AR043369-28

MITF from control of pigmentation to melanoma risk

National Institutes of Health

Grant: 5R35GM134957-05

Integrative Genomic Analyses of Human Evolution and Adaptation in Africa

FWCI

4.97

Citation Percentile

1.0%

Citation Trend

2021

2022

2023

2024

2025

2026

bronzeLicense: Elsevier Non-Commercial

journalhttp://www.cell.com/article/S0092867421007571/pdf

publisherhttp://www.cell.com/article/S0092867421007571/pdf

publisherhttps://api.elsevier.com/content/article/PII:S0092867421007571?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S0092867421007571?httpAccept=text/plain

journalhttps://doi.org/10.1016/j.cell.2021.06.022

Fields of Study

melanin and skin pigmentationSirtuins and Resveratrol in MedicineRedox biology and oxidative stress03 medical and health sciences0303 health sciencesAnimalsCell LineCohort StudiesCyclic AMPDNA DamageEnzyme InhibitorsGenetic Predisposition to DiseaseHumansMelanocytesMelanosomesMiceMice, Inbred C57BLMicrophthalmia-Associated Transcription FactorMitochondriaMonophenol MonooxygenaseNADP TranshydrogenasesOxidation-ReductionPolymorphism, Single NucleotideProteasome Endopeptidase ComplexProteolysisRNA, MessengerSkin PigmentationUbiquitinUltraviolet RaysZebrafish

MeSH Terms

Cyclic AMPAnimalsCell LineDNA DamageEnzyme InhibitorsHumansMelanocytesMice, Inbred C57BLMitochondriaNADP TranshydrogenasesOxidation-ReductionRNA, MessengerSkin PigmentationMonophenol MonooxygenaseUltraviolet RaysZebrafishCohort StudiesGenetic Predisposition to DiseaseMelanosomesPolymorphism, Single NucleotideUbiquitinProteasome Endopeptidase ComplexMiceMicrophthalmia-Associated Transcription FactorProteolysis

Keywords

Microphthalmia-associated transcription factorBiologyMelaninTyrosinaseHuman skinMelanosomeGeneticsBiochemistryEnzymeUVBPigmentationMitfRedox RegulationNicotinamide Nucleotide TranshydrogenaseProteasome Endopeptidase Complex572610Polymorphism, Single NucleotideCell LineCohort StudiesMicehttps://purl.org/becyt/ford/1.6Cyclic AMPNADP TranshydrogenasesAnimalsHumansGenetic Predisposition to Disease03.02. Klinikai orvostanEnzyme Inhibitorshttps://purl.org/becyt/ford/1MelanosomesMonophenol Monooxygenase03.01. Általános orvostudományMitochondriaMice, Inbred C57BLProteolysisMelanocytesOxidation-ReductionDNA Damage

Sustainable Development Goals

SDG 3: 3. Good health

NNT mediates redox-dependent pigmentation via a UVB- and MITF-independent mechanism

FAIR Checklist

Authors (53)

Funding (24 grants)

Impact

Open Access

Topics

Annotations (Europe PMC)