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ELAVL4, splicing, and glutamatergic dysfunction precede neuron loss in MAPT mutation cerebral organoids

Cell(2021)10.1016/j.cell.2021.07.003Source: DataRank Database

ELAVL4, splicing, and glutamatergic dysfunction precede neuron loss in MAPT mutation cerebral organoids is a research paper published in Cell (2021). On theSindex it has a DataRank of 0. It has been cited 166 times.

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Scored on demand from live citation data

Open Access166 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (39 grants)Impact (FWCI 8.59)OA: greenTopics (70)IDs (PubMed, PMC, OpenAlex)Annotations (4)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (25)

M. Catarina Silva ORCID,Kristen Whitney ORCID,Taylor Bertucci ORCID,Joshua Berlind ORCID,Jesse D. Lai ORCID

Live enrichment

PubMed:34314701 PMC:PMC8635409 OpenAlex:https://openalex.org/W3183726003

National Institutes of Health

Grant: AG046374

New York State Stem Cell Science

Grant: C029158

National Institute of Neurological Disorders and Stroke

Grant: R35 NS097277

National Institute of Neurological Disorders and Stroke

Grant: F31NS117075

New York Genome Center

Grant: U54NS092089

New York Genome Center

Grant: U01AG045390

U.S. Department of Defense

Grant: W81XWH-21-1-0168

U.S. Department of Defense

Grant: W81XWH-21-1-0131

U.S. Department of Defense

Grant: W81XWH-20-1-0424

National Institute on Aging

Grant: R01 AG056293

National Institute on Aging

Grant: 2R01NS097850

NIA NIH HHS

Grant: R01 AG054008

NINDS NIH HHS

Grant: R56 NS110890

NINDS NIH HHS

Grant: RF1 NS110890

NINDS NIH HHS

Grant: R01 NS095252

NIA NIH HHS

Grant: K01 AG046374

NIH HHS

Grant: S10 OD026880

NIA NIH HHS

Grant: P50 AG005681

NINDS NIH HHS

Grant: R01 NS110890

NIA NIH HHS

Grant: P30 AG066444

NINDS NIH HHS

Grant: R01 NS097850

Eisai

Harrington Discovery Institute, University Hospitals

New York Stem Cell Foundation

AbbVie

Sächsische Aufbaubank

Tau Consortium

Association for Frontotemporal Degeneration

Denali Therapeutics

Alzheimer's Drug Discovery Foundation

Hope Center for Neurological Disorders

Rainwater Charitable Foundation

ALS Association

GlaxoSmithKline

Biogen

Genentech

BrightFocus Foundation

California Institute for Regenerative Medicine

John Douglas French Alzheimer's Foundation

FWCI

8.59

Citation Percentile

1.0%

Citation Trend

2021

2022

2023

2024

2025

2026

greenLicense: http://www.elsevier.com/open-access/userlicense/1.0/

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/8635409

publisherhttps://api.elsevier.com/content/article/PII:S0092867421008291?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S0092867421008291?httpAccept=text/plain

journalhttps://doi.org/10.1016/j.cell.2021.07.003

Fields of Study

RNA regulation and diseaseRNA Research and SplicingPluripotent Stem Cells ResearchAutophagyBiomarkersBody PatterningCell DeathCell LineCerebrumELAV-Like Protein 4Glutamic AcidHumansHydrazonesLysosomesMorpholinesMutationNeuronsOrganoidsPhosphorylationPyrimidinesRNA SplicingSignal TransductionStress GranulesSynapsesUp-Regulationtau Proteins

MeSH Terms

ELAV-Like Protein 4Stress GranulesAutophagyCell LineHumansHydrazonesLysosomesMorpholinesMutationNeuronsOrganoidsPhosphorylationPyrimidinesRNA SplicingSynapsesSignal TransductionBiomarkersUp-Regulationtau ProteinsCell DeathGlutamic AcidBody PatterningCerebrum

Keywords

BiologyRNA splicingGlutamatergicOrganoidMutationGeneticsNeuroscienceAlternative splicingExonGeneGlutamate receptorRNASplicingAutophagyFrontotemporal DementiaOrganoidsTauopathyMaptSynaptic SignalingGlutamatergic NeuronsElavl4

Sustainable Development Goals

SDG 0: Good health and well-being