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Human TBK1 deficiency leads to autoinflammation driven by TNF-induced cell death

Cell(2021)10.1016/j.cell.2021.07.026Source: DataRank Database

Human TBK1 deficiency leads to autoinflammation driven by TNF-induced cell death is a research paper published in Cell (2021). On theSindex it has a DataRank of 0. It has been cited 140 times.

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0DataRank · unranked

Scored on demand from live citation data

Open Access140 citations

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datarank_citation_only_1hop_v6· scope data_onlyMethodology

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Enrichment:Funding (12 grants)Impact (FWCI 7.11)OA: bronzeTopics (105)IDs (PubMed, PMC, OpenAlex)Annotations (1)SDGs (2)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (25)

Michael Markson ORCID,Diana Legarda ORCID,Roosheel S. Patel ORCID,Mark Chan ORCID,Louise Malle ORCID

Live enrichment

PubMed:34363755 PMC:PMC8380741 OpenAlex:https://openalex.org/W3190205340

NIAID

Grant: T32 AI007647

NIAID

Grant: F31 AI138363

NIAID

Grant: R01 AI151029

NIAID

Grant: R01 AI148963

NIAID

Grant: R01 AI127372

TÜBİTAK

Grant: 315S096

NIH

Grant: AI126036

NIH

Grant: AI052417

UK Research and Innovation

Grant: MR/S032304/1

The genetic basis of invasive meningococcal disease

NIAID NIH HHS

Grant: R01 AI052417

National Human Genome Research Institute

Icahn School of Medicine at Mount Sinai

FWCI

7.11

Citation Percentile

1.0%

Citation Trend

2021

2022

2023

2024

2025

2026

bronzeLicense: Elsevier Non-Commercial

journalhttp://www.cell.com/article/S0092867421008850/pdf

publisherhttp://www.cell.com/article/S0092867421008850/pdf

publisherhttps://api.elsevier.com/content/article/PII:S0092867421008850?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S0092867421008850?httpAccept=text/plain

journalhttps://doi.org/10.1016/j.cell.2021.07.026

Fields of Study

interferon and immune responsesCell death mechanisms and regulationInflammasome and immune disorders0301 basic medicine0303 health sciences03 medical and health sciencesA549 CellsAdaptor Proteins, Signal TransducingApoptosisAutoimmunityBrainCell DeathCytokinesDeubiquitinating Enzyme CYLDFemaleHEK293 CellsHomozygoteHumansI-kappa B KinaseImmunophenotypingInflammationInterferon Type IInterferon-gammaLoss of Function MutationMalePedigreePhosphorylationProtein Serine-Threonine KinasesReceptor-Interacting Protein Serine-Threonine KinasesReceptors, Pattern RecognitionToll-Like Receptor 3TranscriptomeTumor Necrosis Factor-alphaVesiculovirus

MeSH Terms

A549 CellsLoss of Function MutationDeubiquitinating Enzyme CYLDBrainFemaleHomozygoteHumansInflammationInterferon Type IInterferon-gammaMalePedigreePhosphorylationTumor Necrosis Factor-alphaAutoimmunityImmunophenotypingCytokinesCell DeathApoptosisProtein Serine-Threonine KinasesVesiculovirusAdaptor Proteins, Signal TransducingReceptors, Pattern RecognitionToll-Like Receptor 3I-kappa B KinaseReceptor-Interacting Protein Serine-Threonine KinasesHEK293 CellsTranscriptome

Keywords

TANK-binding kinase 1BiologyNecroptosisTumor necrosis factor alphaIn vivoInflammationIκB kinaseImmunologyEx vivoMutationCancer researchProgrammed cell deathNF-κBCell biologyKinaseGeneticsProtein kinase AApoptosisTnf AlphaAutoinflammationIrf3Ripk1Interferon Type IViral SusceptibilityIkkeTbk1 DeficiencyMaleCell DeathHomozygoteBrainAutoimmunityDeubiquitinating Enzyme CYLDI-kappa B KinaseImmunophenotypingPedigreeInterferon-gammaHEK293 CellsA549 CellsLoss of Function MutationCytokinesHumansFemaleAdaptor Proteins, Signal Transducing

Sustainable Development Goals

SDG 3: 3. Good healthSDG 0: Good health and well-being

Human TBK1 deficiency leads to autoinflammation driven by TNF-induced cell death

FAIR Checklist

Authors (25)

Funding (12 grants)

Impact

Open Access

Topics

Annotations (Europe PMC)