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Positive selection CRISPR screens reveal a druggable pocket in an oligosaccharyltransferase required for inflammatory signaling to NF-κB

Cell(2024)10.1016/j.cell.2024.03.022Source: DataRank Database

Positive selection CRISPR screens reveal a druggable pocket in an oligosaccharyltransferase required for inflammatory signaling to NF-κB is a research paper published in Cell (2024). On theSindex it has a DataRank of 0. It has been cited 48 times.

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Scored on demand from live citation data

Open Access48 citations

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Linked data & code

gen refsnp hpa refseq uniprot pdb

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (9 grants)Impact (FWCI 9.19)OA: hybridTopics (51)IDs (PubMed, PMC, OpenAlex)Annotations (6)SDGs (2)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (15)

Ana S. Ramίrez ORCID,Marta Baro ORCID,Lixia He,Mudra Hegde ORCID,Vidyasagar Koduri ORCID

Live enrichment

PubMed:38670073 PMC:PMC11149550 OpenAlex:https://openalex.org/W4395469468

NCI NIH HHS

Grant: K08 CA252611

NCI NIH HHS

Grant: R35 CA210068

NCI NIH HHS

Grant: T32 CA009172

Swiss National Science Foundation

Grant: 310030

NCI NIH HHS

Grant: R01 CA240418

Swiss National Science Foundation

Grant: 173709

GlycoSTART: Structure and function of eukaryotic oligosaccharyltransferase

National Institutes of Health

Grant: 2R35CA210068-08

The von Hippel-Lindau Tumor Suppressor Gene and Kidney Cancer: Insights into Oxygen Sensing and Treating Cancers Caused by Undruggable Mutations

National Institutes of Health

Grant: 5K08CA252611-02

Mechanism of Action of Spautin-1, A Novel Degrader of IKZF1

National Institutes of Health

Grant: 5R01CA240418-03

OST Inhibition in NSCLC

FWCI

9.19

Citation Percentile

1.0%

Citation Trend

2024

2025

2026

hybridLicense: cc-by-nc-nd

journalhttp://www.cell.com/article/S0092867424003131/pdf

publisherhttp://www.cell.com/article/S0092867424003131/pdf

publisherhttps://api.elsevier.com/content/article/PII:S0092867424003131?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S0092867424003131?httpAccept=text/plain

journalhttps://doi.org/10.1016/j.cell.2024.03.022

Fields of Study

NF-κB Signaling Pathwaysinterferon and immune responsesImmune Response and Inflammation0301 basic medicine03 medical and health sciences

MeSH Terms

AnimalsGlycosylationHexosyltransferasesHumansInflammationLipopolysaccharidesMembrane ProteinsSignal TransductionNF-kappa BCatalytic DomainCryoelectron MicroscopyToll-Like Receptor 4MiceHEK293 CellsClustered Regularly Interspaced Short Palindromic RepeatsCRISPR-Cas Systems

Keywords

BiologyDruggabilityCRISPRSelection (genetic algorithm)Computational biologyGeneticsBioinformaticsGeneNF-κBToll-like receptorsN-GlycosylationOligosaccharyltransferaseInhibition MechanismCrispr ScreeningLipopolysaccharidesInflammationGlycosylationCryoelectron MicroscopyNF-kappa BMembrane ProteinsToll-Like Receptor 4MiceHEK293 CellsHexosyltransferasesCatalytic DomainHumansAnimalsClustered Regularly Interspaced Short Palindromic RepeatsCRISPR-Cas SystemsSignal Transduction

Sustainable Development Goals

SDG 3: 3. Good healthSDG 0: Good health and well-being