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Structure-based discovery of CFTR potentiators and inhibitors

Cell(2024)10.1016/j.cell.2024.04.046Source: DataRank Database

Structure-based discovery of CFTR potentiators and inhibitors is a research paper published in Cell (2024). On theSindex it has a DataRank of 0. It has been cited 32 times.

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0DataRank · unranked

Scored on demand from live citation data

Open Access32 citations

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Linked data & code

gen emdb uniprot pdb

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (8 grants)Impact (FWCI 9.15)OA: hybridTopics (47)IDs (PubMed, PMC, OpenAlex)Annotations (4)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (14)

Anat Levit Kaplan,Jesper Levring ORCID,Jürgen Einsiedel ORCID,Stephanie Tiedt,Katharina Distler ORCID

Live enrichment

PubMed:38810646 PMC:PMC11262615 OpenAlex:https://openalex.org/W4399107390

NIH

Grant: GM71896

NIGMS NIH HHS

Grant: R01 GM071896

NIGMS NIH HHS

Grant: R35 GM122481

Deutsche Forschungsgemeinschaft

Grant: unidentified

unidentified

National Institutes of Health

Grant: 5R35GM122481-05

Development and Testing of New Computational Methods for Ligand Discovery and Mechanism

Deutsche Forschungsgemeinschaft

Howard Hughes Medical Institute

Genentech

FWCI

9.15

Citation Percentile

1.0%

Citation Trend

2024

2025

2026

hybridLicense: cc-by

journalhttp://www.cell.com/article/S0092867424004720/pdf

publisherhttp://www.cell.com/article/S0092867424004720/pdf

publisherhttps://api.elsevier.com/content/article/PII:S0092867424004720?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S0092867424004720?httpAccept=text/plain

journalhttps://doi.org/10.1016/j.cell.2024.04.046

Fields of Study

Cystic Fibrosis Research AdvancesAdvanced biosensing and bioanalysis techniquesBacterial biofilms and quorum sensing0301 basic medicine03 medical and health sciences

MeSH Terms

Allosteric SiteAminophenolsAnimalsCystic FibrosisHumansLigandsQuinolonesCystic Fibrosis Transmembrane Conductance RegulatorCryoelectron MicroscopyDrug DiscoveryMolecular Docking Simulation

Keywords

PotentiatorIvacaftorCystic fibrosis transmembrane conductance regulatorCystic fibrosisDrug discoveryBiologySmall moleculeAllosteric regulationDocking (animal)PharmacologyIon channelComputational biologyBiochemistryMedicineEnzymeGeneticsInhibitorsABC transporterAnion ChannelLigand DiscoveryPotentiatorsLarge-scale DockingCryoelectron MicroscopyQuinolonesAminophenolsLigandsArticleMolecular Docking SimulationHumansAnimalsAllosteric Site