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Blockade of LAG-3 and PD-1 leads to co-expression of cytotoxic and exhaustion gene modules in CD8+ T cells to promote antitumor immunity

Cell(2024)10.1016/j.cell.2024.06.036Source: DataRank Database

Blockade of LAG-3 and PD-1 leads to co-expression of cytotoxic and exhaustion gene modules in CD8+ T cells to promote antitumor immunity is a research paper published in Cell (2024). On theSindex it has a DataRank of 0. It has been cited 157 times.

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0DataRank · unranked

Scored on demand from live citation data

Open Access157 citations

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Linked data & code

geo bioproject dbgap nct doi

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (9 grants)Impact (FWCI 29.20)OA: bronzeTopics (42)IDs (PubMed, PMC, OpenAlex)Annotations (5)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (14)

Carly Cardello ORCID,Feng Shan ORCID,Lilit Karapetyan ORCID,Sheryl Kunning ORCID,Cindy Sander ORCID

Live enrichment

PubMed:39121849 PMC:PMC11346583 OpenAlex:https://openalex.org/W4401421807

Bristol-Myers Squibb Co

Grant: CA224-070

NIH

Grant: CA082084

NIH

Grant: S10OD028483

NIH

Grant: CA254865

Université Pierre et Marie Curie

Grant: CCSG P30 CA047904

NCI NIH HHS

Grant: P30 CA047904

NCI NIH HHS

Grant: T32 CA082084

NCI NIH HHS

Grant: P50 CA254865

University of Pittsburgh

FWCI

29.20

Citation Percentile

1.0%

Influential Citations

Citation Trend

2024

2025

2026

bronzeLicense: http://www.elsevier.com/open-access/userlicense/1.0/

journalhttp://www.cell.com/article/S0092867424007104/pdf

publisherhttp://www.cell.com/article/S0092867424007104/pdf

publisherhttps://api.elsevier.com/content/article/PII:S0092867424007104?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S0092867424007104?httpAccept=text/plain

journalhttps://doi.org/10.1016/j.cell.2024.06.036

Fields of Study

Cancer Immunotherapy and BiomarkersCAR-T cell therapy researchImmune Cell Function and InteractionMedicine

MeSH Terms

Positive Regulatory Domain I-Binding Factor 1NivolumabImmune Checkpoint InhibitorsLymphocyte Activation Gene 3 ProteinCell DifferentiationCytotoxicity, ImmunologicHigh Mobility Group ProteinsHumansMelanomaSignal TransductionAntigens, CDCD8-Positive T-LymphocytesBasic-Leucine Zipper Transcription FactorsProgrammed Cell Death 1 Receptor

Keywords

BiologyCytotoxic T cellBlockadeImmunityCD8Cell biologyGene expressionGeneLagCancer researchImmunologyImmune systemGeneticsReceptorIn vitroAntitumor immunityPD-1Inhibitory receptorsCombination ImmunotherapyLag-3Checkpoint BlockadeAdvanced MelanomaT Cell ExhaustionCd8(+) T cell Transcriptional Profiles

Sustainable Development Goals

SDG 0: Zero hunger

Blockade of LAG-3 and PD-1 leads to co-expression of cytotoxic and exhaustion gene modules in CD8+ T cells to promote antitumor immunity

FAIR Checklist

Authors (14)

Funding (9 grants)

Impact

Open Access

Topics

Annotations (Europe PMC)