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The Classical Complement Pathway Mediates Microglia-Dependent Remodeling of Spinal Motor Circuits during Development and in SMA

Cell Reports(2019)10.1016/j.celrep.2019.11.013Source: DataRank Database

The Classical Complement Pathway Mediates Microglia-Dependent Remodeling of Spinal Motor Circuits during Development and in SMA is a research paper published in Cell Reports (2019). On theSindex it has a DataRank of 3.1. It has been cited 129 times, with 114 citing works in its 1-hop citation network.

N/A

3.1DataRank · unranked

Scored on demand from live citation data

129 citations · 114 citing works in its network

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Linked data & code

DataRank reads this dataset's downstream impact straight off the citation graph — no black box, no proprietary weighting. How is this computed?

›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (7 grants)Impact (FWCI 8.28)OA: goldTopics (68)Linked Datasets (6)DataCite Reuse (6)IDs (PubMed, OpenAlex)

FAIR Checklist

Context only (not used in score)

Findable (2/2)

Has DOI
Indexed in repositories

Accessible (0/2)

Interoperable (2/2)

DataCite relations
Linked datasets

Reusable (0/3)

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DataRank Breakdown

Base Score 23%Citation Network 77%

Base Score Contribution

0.730

From this paper's citation signal

Citation Network Contribution

2.4

From 100 citing papers with measurable signal

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Top 5 citers driving the network score

Ranked by each citer's contribution to N(p) — log1p(C_q) divided by its reference count — out of 114 citers.

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The neuronal pentraxin Nptx2 regulates complement activity and restrains microglia-mediated synapse loss in neurodegeneration
Science Translational Medicine2023153 citations52 referencesContributes 0.097
Biodistribution of onasemnogene abeparvovec DNA, mRNA and SMN protein in human tissue
Nature Medicine2021108 citations64 referencesContributes 0.073
Microglia‐synapse engulfment via PtdSer‐TREM2 ameliorates neuronal hyperactivity in Alzheimer's disease models
The EMBO Journal2023121 citations68 referencesContributes 0.071
Microglia mediate neurocognitive deficits by eliminating C1q-tagged synapses in sepsis-associated encephalopathy
Science Advances2023149 citations78 referencesContributes 0.064

Authors (8)

Nicolas Delestrée ORCID,Emily V. Fletcher ORCID,John G. Pagiazitis,Sethu Sankaranarayanan ORCID,Ted A. Yednock

Live enrichment

PubMed:31801075 OpenAlex:https://openalex.org/W2993235793

National Institutes of Health

Grant: R01-NS078375

U.S. Department of Defense

Grant: GR.10235006

National Institute on Alcohol Abuse and Alcoholism

Grant: R01-AA027079

National Institutes of Health

Grant: 1R01AA027079-01

Mechanisms of synaptic loss by the classical complement pathway in motor circuit development and disease

National Institutes of Health

Grant: 1R01NS078375-01

Mechanisms of Central Synaptic Dysfunction in SMA

NIAAA NIH HHS

Grant: R01 AA027079

NINDS NIH HHS

Grant: R01 NS078375

FWCI

8.28

Citation Percentile

1.0%

Citation Trend

2018

2020

2021

2022

2023

2024

2025

2026

goldLicense: cc-by-nc-nd

journalhttp://www.cell.com/article/S2211124719314846/pdf

publisherhttp://www.cell.com/article/S2211124719314846/pdf

publisherhttps://api.elsevier.com/content/article/PII:S2211124719314846?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S2211124719314846?httpAccept=text/plain

journalhttps://doi.org/10.1016/j.celrep.2019.11.013

Fields of Study

Neurogenetic and Muscular Disorders ResearchNeuroinflammation and Neurodegeneration MechanismsSpinal Cord Injury Research0301 basic medicine0303 health sciences03 medical and health sciencesAnimalsChild, PreschoolComplement C1qComplement Pathway, ClassicalDisease Models, AnimalHumansMaleMiceMice, Inbred C57BLMicrogliaMotor NeuronsMuscular Atrophy, SpinalSynapses

MeSH Terms

AnimalsChild, PreschoolComplement Pathway, ClassicalDisease Models, AnimalHumansMaleMice, Inbred C57BLMotor NeuronsMuscular Atrophy, SpinalSynapsesComplement C1qMicrogliaMice

Keywords

SMA*NeuroscienceMicrogliaComplement (music)Spinal muscular atrophyBiologyMotor neuronCell biologySpinal cordInflammationImmunologyPhenotypeGeneGeneticsComputer scienceMaleMotor NeuronsQH301-705.5Complement C1qArticleMice, Inbred C57BLMuscular Atrophy, SpinalDisease Models, AnimalMiceChild, PreschoolSynapsesAnimalsHumansComplement Pathway, ClassicalBiology (General)C1qSMNclassical complement pathwayproprioceptive neuronsensory-motor circuitsynapse

Additional file 1 of Increased chitotriosidase 1 concentration following nusinersen treatment in spinal muscular atrophy

10.6084/m9.figshare.15071513.v1figshare

Additional file 1 of Increased chitotriosidase 1 concentration following nusinersen treatment in spinal muscular atrophy

10.6084/m9.figshare.15071513figshare

Additional file 2 of Increased chitotriosidase 1 concentration following nusinersen treatment in spinal muscular atrophy

10.6084/m9.figshare.15071516.v1figshare

Additional file 2 of Increased chitotriosidase 1 concentration following nusinersen treatment in spinal muscular atrophy

10.6084/m9.figshare.15071516figshare

Additional file 3 of Increased chitotriosidase 1 concentration following nusinersen treatment in spinal muscular atrophy

10.6084/m9.figshare.15071519.v1figshare

Additional file 3 of Increased chitotriosidase 1 concentration following nusinersen treatment in spinal muscular atrophy

10.6084/m9.figshare.15071519figshare