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Structural Insights into the SPRED1-Neurofibromin-KRAS Complex and Disruption of SPRED1-Neurofibromin Interaction by Oncogenic EGFR

Cell Reports(2020)10.1016/j.celrep.2020.107909Source: DataRank Database

Structural Insights into the SPRED1-Neurofibromin-KRAS Complex and Disruption of SPRED1-Neurofibromin Interaction by Oncogenic EGFR is a research paper published in Cell Reports (2020). On theSindex it has a DataRank of 0. It has been cited 69 times.

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Open Access69 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (7 grants)Impact (FWCI 3.50)OA: goldTopics (60)IDs (PubMed, OpenAlex)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (10)

Evan Markegard,Srisathiyanarayanan Dharmaiah ORCID,Anatoly Urisman ORCID,Matthew Drew ORCID,Dominic Esposito ORCID

Live enrichment

PubMed:32697994 OpenAlex:https://openalex.org/W3044205040

NCRR NIH HHS

Grant: S10 RR029205

NCI NIH HHS

Grant: R35 CA197709

NIGMS NIH HHS

Grant: P30 GM124165

NCI NIH HHS

Grant: T32 CA108462

Intramural NIH HHS

Grant: Z99 CA999999

CCR NIH HHS

Grant: HHSN261200800001C

NCI NIH HHS

Grant: HHSN261200800001E

FWCI

3.50

Citation Percentile

0.9%

Citation Trend

2020

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2026

goldLicense: cc-by

journalhttp://www.cell.com/article/S2211124720308901/pdf

publisherhttp://www.cell.com/article/S2211124720308901/pdf

publisherhttps://api.elsevier.com/content/article/PII:S2211124720308901?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S2211124720308901?httpAccept=text/plain

journalhttps://doi.org/10.1016/j.celrep.2020.107909

Fields of Study

Fibroblast Growth Factor ResearchHippo pathway signaling and YAP/TAZWnt/β-catenin signaling in development and cancerAdaptor Proteins, Signal TransducingAmino Acid SequenceCafe-au-Lait SpotsCatalytic DomainDNA Mutational AnalysisEpidermal Growth FactorErbB ReceptorsGuanosine TriphosphateHEK293 CellsHumansK562 CellsNeurofibromatosis 1Neurofibromin 1OncogenesPhosphorylationPoint MutationProtein BindingProtein DomainsProtein Interaction MapsProto-Oncogene Proteins p21(ras)Signal TransductionLegius syndrome

MeSH Terms

Protein DomainsAmino Acid SequenceDNA Mutational AnalysisEpidermal Growth FactorGuanosine TriphosphateHumansNeurofibromatosis 1OncogenesPhosphorylationProtein BindingSignal TransductionProto-Oncogene Proteins p21(ras)Point MutationCafe-au-Lait SpotsK562 CellsCatalytic DomainNeurofibromin 1Adaptor Proteins, Signal TransducingHEK293 CellsProtein Interaction MapsErbB Receptors

Keywords

Neurofibromin 1KRASCancer researchCell biologyBiologyCancerNeurofibromatosisGeneticsColorectal cancerLegius syndromeRAS-RAF-ERK pathwayRASopathyRasGAPneurofibromatosis type 1

Sustainable Development Goals

SDG 0: Good health and well-being