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High-Throughput CRISPR Screening Identifies Genes Involved in Macrophage Viability and Inflammatory Pathways

Cell Reports(2020)10.1016/j.celrep.2020.108541Source: DataRank Database

High-Throughput CRISPR Screening Identifies Genes Involved in Macrophage Viability and Inflammatory Pathways is a research paper published in Cell Reports (2020). On theSindex it has a DataRank of 0. It has been cited 59 times.

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Open Access59 citations

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datarank_citation_only_1hop_v6· scope data_onlyMethodology

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Enrichment:Funding (12 grants)Impact (FWCI 1.94)OA: goldTopics (104)IDs (PubMed, PMC, OpenAlex)Annotations (2)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (14)

Apple Cortez Vollmers ORCID,Allyson Capili ORCID,Michael Boettcher ORCID,Aaron Shulkin ORCID,Michele Ramos Correa ORCID

Live enrichment

PubMed:33378675 PMC:PMC7901356 OpenAlex:https://openalex.org/W3113956062

National Institutes of Health

Grant: R21 AI142165

National Institutes of Health

Grant: R03 AI131019-01

National Institutes of Health

Grant: T32 GM008646

National Institutes of Health

Grant: U01 CA217882

NIGMS NIH HHS

Grant: R25 GM104552

NIAID NIH HHS

Grant: R03 AI131019

National Institutes of Health

Grant: 5R03AI131019-02

Screening for lincRNAs involved in NFKB signaling

National Institutes of Health

Grant: 5T32GM008646-05

GRADUATE TRAINING IN MCD BIOLOGY

National Institutes of Health

Grant: 1R21AI142165-01A1

Determining the role for lncRNAs in controlling inflammation

National Institutes of Health

Grant: 1U01CA217882-01

The Cancer Target Discovery and Development Network at UCSF

Howard Hughes Medical Institute

National Institutes of Health

FWCI

1.94

Citation Percentile

0.9%

Influential Citations

Citation Trend

2021

2022

2023

2024

2025

2026

goldLicense: cc-by-nc-nd

journalhttp://www.cell.com/article/S2211124720315308/pdf

GOLDhttps://www.cell.com/article/S2211124720315308/pdf

publisherhttp://www.cell.com/article/S2211124720315308/pdf

publisherhttps://api.elsevier.com/content/article/PII:S2211124720315308?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S2211124720315308?httpAccept=text/plain

Fields of Study

Neuroinflammation and Neurodegeneration MechanismsImmune cells in cancerCRISPR and Genetic EngineeringMedicineBiology0301 basic medicine0303 health sciences03 medical and health sciences

MeSH Terms

RNA, Guide, CRISPR-Cas SystemsAnimalsCell LineCell SurvivalFlow CytometryGene Expression RegulationHumansInflammationMacrophagesTumor Necrosis Factor-alphaSignal TransductionNF-kappa BRNA, Guide, Kinetoplastida3' Untranslated RegionsMiceHigh-Throughput Screening AssaysHEK293 CellsClustered Regularly Interspaced Short Palindromic RepeatsCRISPR-Cas Systems

Keywords

CRISPRBiologyEffectorGenetic screenGeneCell sortingFunction (biology)MacrophageImmune systemCell biologyComputational biologyGeneticsPhenotypeCellNF-kappaBViabilityTNFInflammationNF-κB3′ UtrCrispr ScreenGene Expression Regulation (mesh)High-Throughput Screening Assays (mesh)Medical PhysiologyCell Survival (mesh)RNA, Guide, CRISPR-Cas SystemsMice31 Biological sciences (for-2020)2.1 Biological and endogenous factorsAnimals (mesh)CRISPR-Cas Systems (mesh)Clustered Regularly Interspaced Short Palindromic Repeats3' Untranslated RegionsHumans (mesh)Generic health relevance (hrcs-hc)NF-kappa BMice (mesh)Flow Cytometry (mesh)Biological SciencesFlow Cytometry3' Untranslated Regions (mesh)1116 Medical Physiology (for)BiotechnologySignal Transduction570Inflammation (mesh)Cell Survival1.1 Normal biological development and functioningTumor Necrosis Factor-alpha (mesh)0601 Biochemistry and Cell Biology (for)Biotechnology (rcdc)ArticleClustered Regularly Interspaced Short Palindromic Repeats (mesh)Cell LineAnimalsHumans1.1 Normal biological development and functioning (hrcs-rac)HEK293 Cells (mesh)Genetics (rcdc)Tumor Necrosis Factor-alphaInflammatory and immune systemMacrophages2.1 Biological and endogenous factors (hrcs-rac)3101 Biochemistry and Cell Biology (for-2020)Inflammatory and immune system (hrcs-hc)High-Throughput Screening AssaysHEK293 CellsGene Expression RegulationMacrophages (mesh)Cell Line (mesh)RNASignal Transduction (mesh)Biochemistry and Cell BiologyGeneric health relevanceCRISPR-Cas SystemsGuideNF-kappa B (mesh)

Sustainable Development Goals

SDG 3: 3. Good health