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Proteopathic tau primes and activates interleukin-1β via myeloid-cell-specific MyD88- and NLRP3-ASC-inflammasome pathway

Cell Reports(2021)10.1016/j.celrep.2021.109720Source: DataRank Database

Proteopathic tau primes and activates interleukin-1β via myeloid-cell-specific MyD88- and NLRP3-ASC-inflammasome pathway is a research paper published in Cell Reports (2021). On theSindex it has a DataRank of 0. It has been cited 89 times.

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Open Access89 citations

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cellosaurus gen arrayexpress

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

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Enrichment:Funding (27 grants)OA: goldTopics (80)IDs (PubMed, PMC)Annotations (3)SDGs (1)

FAIR Checklist

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Findable (1/2)

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Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (18)

Nicole Maphis ORCID,Jessica Binder ORCID,Devon Chisholm,Lea L. Weston,Walter Duran

Live enrichment

PubMed:34551296 PMC:PMC8491766

NIGMS NIH HHS

Grant: P20 GM121176

National Institutes of Health

Grant: P20GM121176-04

NIA NIH HHS

Grant: P30 AG013854

NCI NIH HHS

Grant: P30 CA118100

National Institutes of Health

Grant: R21NS093442

National Institutes of Health

Grant: RF1NS083704-05A1

NIA NIH HHS

Grant: P30 AG072977

NINDS NIH HHS

Grant: R01 NS116051

NINDS NIH HHS

Grant: R21 NS084210

NINDS NIH HHS

Grant: R24 NS104160

NIGMS NIH HHS

Grant: K12 GM088021

NIA NIH HHS

Grant: P20 AG068077

NINDS NIH HHS

Grant: R01 NS083704

NINDS NIH HHS

Grant: RF1 NS083704

NINDS NIH HHS

Grant: R21 NS077089

NINDS NIH HHS

Grant: UF1 NS100598

National Institutes of Health

Grant: 1R21NS093442-01A1

Light-based regulation of autophagy processing to target pathological forms of tau

National Institutes of Health

Grant: 5P30AG013854-05

CORE--CLINICAL

National Institutes of Health

Grant: 2RF1NS083704-05A1

The Role of Inflammasome Signaling in Tauopathies

National Institutes of Health

Grant: 5R01NS116051-05

Molecular mechanisms of excitatory postsynaptic diversity

National Institutes of Health

Grant: 7R21NS077089-02

The role of microglial-and neuron-specific MyD88 signaling in tauopathies

National Institutes of Health

Grant: 5P20AG068077-03

New Mexico Alzheimer's Disease Research Center

National Institutes of Health

Grant: 3P20GM121176-04S1

Effect of vaping on lung immunity

Genentech

Université de Lausanne

National Institute on Aging

University of New Mexico

goldLicense: CC BY NC ND

publisherhttps://doi.org/10.1016/j.celrep.2021.109720

repositoryhttps://doaj.org/article/d7ff525d710c4c41847bd98e6f7f0a7b

repositoryhttp://europepmc.org/pmc/articles/PMC8491766

repositoryhttps://orbilu.uni.lu/handle/10993/61066

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/8491766

Fields of Study

0301 basic medicine0303 health sciences03 medical and health sciences

MeSH Terms

MicrogliaCells, CulturedMyeloid CellsAnimalsMice, Inbred C57BLHumansMiceTauopathiesDisease Models, AnimalDoxorubicinCaspase 1tau ProteinsNF-kappa BSignal TransductionDown-RegulationInterleukin-1betaMyeloid Differentiation Factor 88CARD Signaling Adaptor ProteinsInflammasomesNLR Family, Pyrin Domain-Containing 3 Protein

Keywords

IL-1βTauMicrogliaASCneuroinflammationTauopathiesMyD88InflammasomesNlrp3Mapttau Proteins/geneticsMyeloid Differentiation Factor 88/metabolismInterleukin-1betaDown-Regulation/drug effectsNLR Family, Pyrin Domain-Containing 3 Protein/geneticsMicroglia/cytologyCaspase 1/metabolismMiceInflammasomes/metabolismMyeloid CellsMyeloid Differentiation Factor 88/geneticsHuman health sciencesBiology (General)Myeloid Cells/cytologyCells, CulturedCaspase 1NF-kappa BMyeloid Cells/metabolismNeurologyInterleukin-1beta/geneticsNLR Family, Pyrin Domain-Containing 3 Protein/metabolismTauopathies/pathologySignal TransductionTauopathies/metabolismQH301-705.5Doxorubicin/pharmacologyDown-Regulationtau ProteinsCARD Signaling Adaptor Proteins/geneticsCARD Signaling Adaptor Proteins/metabolismSciences de la santé humaineGeneral Biochemistry, Genetics and Molecular BiologyArticleMicroglia/metabolismtau Proteins/metabolismNeurologieNLR Family, Pyrin Domain-Containing 3 ProteinAnimalsHumansBiochemistry, Genetics and Molecular Biology (all)CARD Signaling Adaptor ProteinsMice, Inbred C57BLDisease Models, AnimalDoxorubicinInterleukin-1beta/metabolismNF-kappa B/metabolismMyeloid Differentiation Factor 88

Sustainable Development Goals

SDG 3: 3. Good health

Proteopathic tau primes and activates interleukin-1β via myeloid-cell-specific MyD88- and NLRP3-ASC-inflammasome pathway

FAIR Checklist

Authors (18)

Funding (27 grants)

Open Access

Topics

Annotations (Europe PMC)