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TIGER: The gene expression regulatory variation landscape of human pancreatic islets

Cell Reports(2021)10.1016/j.celrep.2021.109807Source: DataRank Database

TIGER: The gene expression regulatory variation landscape of human pancreatic islets is a dataset published in Cell Reports (2021). On theSindex it has a DataRank of 2.2, placing it in the top 9.5% of the data-sharing corpus. It has been cited 103 times, with 66 citing works in its 1-hop citation network.

Top 10%percentile

2.2DataRank

Ranks in the top 10% for downstream scientific impact

Data paper Open Access103 citations · 66 citing works in its network

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Linked data & code

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DataRank reads this dataset's downstream impact straight off the citation graph — no black box, no proprietary weighting. How is this computed?

›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (30 grants)OA: goldTopics (26)IDs (PubMed, PMC)Annotations (4)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (1/3)

Dataset classification

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DataRank Breakdown

Base Score 31%Citation Network 69%

Base Score Contribution

0.697

From this paper's citation signal

Citation Network Contribution

1.5

From 49 citing papers with measurable signal

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Top 5 citers driving the network score

Ranked by each citer's contribution to N(p) — log1p(C_q) divided by its reference count — out of 66 citers.

ColocQuiaL: a QTL-GWAS colocalization pipeline
Bioinformatics202224 citations13 referencesContributes 0.248
Bidirectional Mendelian Randomization and Multiphenotype GWAS Show Causality and Shared Pathophysiology Between Depression and Type 2 Diabetes
Diabetes Care2023166 citations41 referencesContributes 0.125
Understanding islet dysfunction in type 2 diabetes through multidimensional pancreatic phenotyping: The Human Pancreas Analysis Program
Cell Metabolism202273 citations36 referencesContributes 0.120
Circulating spexin levels are influenced by the glycemic status and correlated with pancreatic β-cell function in Chinese subjects
Acta Diabetologica202213 citations34 referencesContributes 0.078
Overture: an open-source genomics data platform
GigaScience20252 citations16 referencesContributes 0.069

Authors (29)

Anthony Piron ORCID,Ignasi Morán ORCID,Marta Guindo-Martínez ORCID,Sílvia Bonàs‐Guarch ORCID,Goutham Atla ORCID

Live enrichment

PubMed:34644572 PMC:PMC8864863

National Institutes of Health

Grant: U01-DK085545

National Institutes of Health

Grant: U01-DK105535

Stiftelsen för Strategisk Forskning

Grant: IRC15-0067

American Diabetes Association

Grant: 1-19-ICTS-068

Government of Spain Ministry of Science and Innovation

Grant: BES-2017-081635

Government of Spain Ministry of Science and Innovation

Grant: BFU2014-54284-R

Medical Research Council

Grant: MR/L02036X/1

Medical Research Council

Grant: WT101033

Wellcome Trust

Grant: 095101

Wellcome Trust

Grant: 106130

Wellcome Trust

Grant: 200837

Wellcome Trust

Grant: 203141

Ministerio de Ciencia e Innovación

Grant: RTI2018-095666-B-I00

European Research Council

Grant: 789055

Horizon 2020 European Innovation Council Fast Track to Innovation

Grant: 667191

Staatssekretariat für Bildung, Forschung und Innovation

Grant: 16.0097

NIDDK NIH HHS

Grant: U01 DK085545

NIDDK NIH HHS

Grant: U01 DK105535

NIDDK NIH HHS

Grant: U01 DK127786

Wellcome Trust

Grant: 200837/Z/16/Z

Research England

European Commission

Horizon 2020 Framework Programme

Imperial College London

Fonds De La Recherche Scientifique - FNRS

European Federation of Pharmaceutical Industries and Associations

National Institute for Health and Care Research

Barcelona Supercomputing Center

NIHR Imperial Biomedical Research Centre

European Research Council

goldLicense: cc-by-nc-nd

publisherhttp://www.cell.com/article/S2211124721012675/pdf

publisherhttps://api.elsevier.com/content/article/PII:S2211124721012675?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S2211124721012675?httpAccept=text/plain

repositoryhttps://upcommons.upc.edu/bitstreams/59fbeb26-41fe-49d8-a367-4b522e8be5ba/download

repositoryhttps://hdl.handle.net/11568/1125014

MeSH Terms

Islets of LangerhansHumansDiabetes Mellitus, Type 2Genetic Predisposition to DiseaseGenomicsGene FrequencyPhenotypeQuantitative Trait LociDatabases, GeneticEuropeGenetic VariationGenome-Wide Association StudyCyclin D2TranscriptomeZinc Transporter 8Epigenome

Keywords

Type 2 diabetesTranscriptomepancreatic isletsepigenomicsBeta cellRna-seqGenome-wide Association Study (Gwas)Allele-specific ExpressionRegulatory VariationExpression Quantitative Trait Locus (Eqtl)