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Loss of FBXO31-mediated degradation of DUSP6 dysregulates ERK and PI3K-AKT signaling and promotes prostate tumorigenesis

Cell Reports(2021)10.1016/j.celrep.2021.109870Source: DataRank Database

Loss of FBXO31-mediated degradation of DUSP6 dysregulates ERK and PI3K-AKT signaling and promotes prostate tumorigenesis is a research paper published in Cell Reports (2021). On theSindex it has a DataRank of 0. It has been cited 39 times.

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0DataRank · unranked

Scored on demand from live citation data

Open Access39 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (13 grants)Impact (FWCI 1.85)OA: goldTopics (82)IDs (PubMed, PMC, OpenAlex)Annotations (1)SDGs (2)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (11)

Loredana Moro ORCID,Rui Qu ORCID,Daniele Simoneschi ORCID,Hyunwoo Cho ORCID,Shaowen Jiang ORCID

Live enrichment

PubMed:34686346 PMC:PMC8577224 OpenAlex:https://openalex.org/W3207868234

National Institutes of Health

Grant: R35-GM136250

National Institutes of Health

Grant: R01-CA76584

National Institutes of Health

Grant: 2T32CA009161

National Research Council

Grant: 70126

NCI NIH HHS

Grant: P30 CA008748

NCI NIH HHS

Grant: R01 CA076584

NCI NIH HHS

Grant: T32 CA009161

NIGMS NIH HHS

Grant: R35 GM136250

National Institutes of Health

Grant: 1R35GM136250-01

Regulation of the cell proliferation by CRL ubiquitin ligases

National Institutes of Health

Grant: 5T32CA009161-30

TRAINING PROGRAM IN MOLECULAR ONCOLOGY AND IMMUNOLOGY

National Institutes of Health

Grant: 5R01CA076584-06

F box Proteins and Deregulated Proteolysis in Cancer

LAM Therapeutics

Howard Hughes Medical Institute

FWCI

1.85

Citation Percentile

0.9%

Citation Trend

2022

2023

2024

2025

2026

goldLicense: CC BY NC ND

journalhttps://doi.org/10.1016/j.celrep.2021.109870

GOLDhttps://doi.org/10.1016/j.celrep.2021.109870

publisherhttps://doi.org/10.1016/j.celrep.2021.109870

publisherhttps://api.elsevier.com/content/article/PII:S2211124721013371?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S2211124721013371?httpAccept=text/plain

Fields of Study

Ubiquitin and proteasome pathwaysEndoplasmic Reticulum Stress and DiseaseGlycosylation and Glycoproteins ResearchMedicineBiology0301 basic medicine03 medical and health sciences0303 health sciences

MeSH Terms

AnimalsAntineoplastic AgentsCyclohexylaminesEnzyme ActivationEnzyme InhibitorsEnzyme StabilityHumansIndenesMaleProstatic NeoplasmsSignal TransductionGene Expression Regulation, NeoplasticMice, SCIDMice, Inbred NODXenograft Model Antitumor AssaysTumor Suppressor ProteinsF-Box ProteinsCullin ProteinsCell Line, TumorExtracellular Signal-Regulated MAP KinasesProto-Oncogene Proteins c-aktMiceDual Specificity Phosphatase 6HEK293 CellsPhosphatidylinositol 3-KinaseProteolysis

Keywords

Ubiquitin ligaseProstate cancerMAPK/ERK pathwayUbiquitinCancer researchChemistryProtein kinase BPI3K/AKT/mTOR pathwayCarcinogenesisDegradation (telecommunications)ProstateSignal transductionCancerMedicineComputer scienceInternal medicineBiochemistryF-box proteinERKBciAKTUbiquitin LigasesCrlDusp6Fbxo31MaleQH301-705.5Antineoplastic AgentsMice, SCIDArticleDual Specificity Phosphatase 6Mice, Inbred NODCell Line, TumorEnzyme StabilityAnimalsHumansBiology (General)Enzyme InhibitorsExtracellular Signal-Regulated MAP KinasesCyclohexylaminesF-Box ProteinsProstatic NeoplasmsCullin ProteinsEnzyme ActivationGene Expression Regulation, NeoplasticHEK293 CellsIndenesPhosphatidylinositol 3-Kinase

Sustainable Development Goals

SDG 3: 3. Good healthSDG 0: Good health and well-being