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Regulatory T cell differentiation is controlled by αKG-induced alterations in mitochondrial metabolism and lipid homeostasis

Cell Reports(2021)10.1016/j.celrep.2021.109911Source: DataRank Database

Regulatory T cell differentiation is controlled by αKG-induced alterations in mitochondrial metabolism and lipid homeostasis is a research paper published in Cell Reports (2021). On theSindex it has a DataRank of 2.5. It has been cited 119 times, with 103 citing works in its 1-hop citation network.

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2.5DataRank · unranked

Scored on demand from live citation data

Open Access119 citations · 103 citing works in its network

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (5 grants)Impact (FWCI 4.99)OA: goldTopics (119)Linked Datasets (10)DataCite Reuse (10)IDs (PubMed, PMC, OpenAlex)Annotations (2)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (2/2)

Has DOI
Indexed in repositories

Accessible (1/2)

Open Access

Interoperable (2/2)

DataCite relations
Linked datasets

Reusable (0/3)

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DataRank Breakdown

Base Score 29%Citation Network 71%

Base Score Contribution

0.718

From this paper's citation signal

Citation Network Contribution

1.8

From 85 citing papers with measurable signal

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Top 5 citers driving the network score

Ranked by each citer's contribution to N(p) — log1p(C_q) divided by its reference count — out of 103 citers.

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Authors (27)

Carmen S. Yong,Amir Foroushani ORCID,Chloé Goldsmith ORCID,Cédric Mongellaz ORCID,Erdinç Sezgin ORCID

Live enrichment

PubMed:34731632 PMC:PMC10167917 OpenAlex:https://openalex.org/W3209847663

Cancer Research UK

Grant: A23982

Cancer Research UK

Grant: C596/A17196

Cancer Research UK

Grant: 23982

Intramural NIH HHS

Grant: ZIA BC011923

French National Research Agency (ANR)

Grant: ANR-11-INBS-0010

FWCI

4.99

Citation Percentile

1.0%

Citation Trend

2021

2022

2023

2024

2025

2026

goldLicense: CC BY NC ND

journalhttp://www.cell.com/article/S221112472101384X/pdf

publisherhttp://www.cell.com/article/S221112472101384X/pdf

publisherhttps://api.elsevier.com/content/article/PII:S221112472101384X?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S221112472101384X?httpAccept=text/plain

journalhttps://doi.org/10.1016/j.celrep.2021.109911

Fields of Study

Immune cells in cancerImmune Cell Function and InteractionEpigenetics and DNA Methylation0301 basic medicine0303 health sciences03 medical and health sciencesAnimalsCell DifferentiationCells, CulturedCytokinesDiacylglycerol O-AcyltransferaseEnergy MetabolismFibrosarcomaForkhead Transcription FactorsHomeostasisHumansImmunotherapy, AdoptiveKetoglutaric AcidsLipid MetabolismMice, Inbred C57BLMice, KnockoutMitochondriaPhenotypeReceptors, Chimeric AntigenSignal TransductionT-Lymphocytes, RegulatoryTh1 CellsMice

MeSH Terms

Receptors, Chimeric AntigenAnimalsCell DifferentiationCells, CulturedEnergy MetabolismFibrosarcomaHomeostasisHumansKetoglutaric AcidsMice, Inbred C57BLMitochondriaPhenotypeSignal TransductionCytokinesImmunotherapy, AdoptiveMice, KnockoutTh1 CellsLipid MetabolismT-Lymphocytes, RegulatoryDiacylglycerol O-AcyltransferaseMiceForkhead Transcription Factors

Keywords

Cell biologyFOXP3CrosstalkMitochondrionCellular differentiationBiologyIntracellularMetabolismCellChemistryBiochemistryImmunologyImmune systemGeneDNA methylationTCA cycleTh1TregMitochondrial MetabolismT Cell DifferentiationLipidomeΑ-ketoglutarateCar T CellsTriacylglyceride SynthesisFibrosarcoma[SDV.BC.BC]Life Sciences [q-bio]/Cellular Biology/Subcellular Processes [q-bio.SC]0601 Biochemistry and Cell BiologyImmunotherapy, AdoptiveT-Lymphocytes, RegulatoryGLUCOSEACTIVATIONMiceHomeostasisBiology (General)Cells, CulturedMice, KnockoutReceptors, Chimeric AntigenDIACYLGLYCEROL ACYLTRANSFERASESEQ DATACell DifferentiationForkhead Transcription FactorsSUCCINATE-DEHYDROGENASEMitochondriaPhenotype[SDV.IMM.IA]Life Sciences [q-bio]/Immunology/Adaptive immunology[SDV.IMM.IA] Life Sciences [q-bio]/Immunology/Adaptive immunologyCytokinesKetoglutaric AcidsLife Sciences & BiomedicineREDUCTIVE GLUTAMINE-METABOLISMSignal TransductionEXPRESSIONQH301-705.5FATEINHIBITION610[SDV.BC.BC] Life Sciences [q-bio]/Cellular Biology/Subcellular Processes [q-bio.SC]AnimalsHumansDiacylglycerol O-AcyltransferaseMTORC1Science & Technology31 Biological sciencesTh1 CellsLipid MetabolismMice, Inbred C57BLKETOGLUTARATE1116 Medical PhysiologyEnergy Metabolism

Sustainable Development Goals

SDG 0: Good health and well-being

Additional file 5 of Ketoglutaric acid can reprogram the immunophenotype of triple-negative breast cancer after radiotherapy and improve the therapeutic effect of anti-PD-L1

10.6084/m9.figshare.26603758.v1figshare

Additional file 5 of Ketoglutaric acid can reprogram the immunophenotype of triple-negative breast cancer after radiotherapy and improve the therapeutic effect of anti-PD-L1

10.6084/m9.figshare.26603758figshare

Additional file 2 of Ketoglutaric acid can reprogram the immunophenotype of triple-negative breast cancer after radiotherapy and improve the therapeutic effect of anti-PD-L1

10.6084/m9.figshare.26603749.v1figshare

Additional file 4 of Ketoglutaric acid can reprogram the immunophenotype of triple-negative breast cancer after radiotherapy and improve the therapeutic effect of anti-PD-L1

10.6084/m9.figshare.26603755.v1figshare

Additional file 3 of Ketoglutaric acid can reprogram the immunophenotype of triple-negative breast cancer after radiotherapy and improve the therapeutic effect of anti-PD-L1

10.6084/m9.figshare.26603752figshare

Additional file 1 of Ketoglutaric acid can reprogram the immunophenotype of triple-negative breast cancer after radiotherapy and improve the therapeutic effect of anti-PD-L1

10.6084/m9.figshare.26603746figshare

Additional file 1 of Ketoglutaric acid can reprogram the immunophenotype of triple-negative breast cancer after radiotherapy and improve the therapeutic effect of anti-PD-L1

10.6084/m9.figshare.26603746.v1figshare

Additional file 3 of Ketoglutaric acid can reprogram the immunophenotype of triple-negative breast cancer after radiotherapy and improve the therapeutic effect of anti-PD-L1

10.6084/m9.figshare.26603752.v1figshare

Additional file 2 of Ketoglutaric acid can reprogram the immunophenotype of triple-negative breast cancer after radiotherapy and improve the therapeutic effect of anti-PD-L1

10.6084/m9.figshare.26603749figshare

Additional file 4 of Ketoglutaric acid can reprogram the immunophenotype of triple-negative breast cancer after radiotherapy and improve the therapeutic effect of anti-PD-L1

10.6084/m9.figshare.26603755figshare