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Single-cell transcriptomics reveals opposing roles of Shp2 in Myc-driven liver tumor cells and microenvironment

Cell Reports(2021)10.1016/j.celrep.2021.109974Source: DataRank Database

Single-cell transcriptomics reveals opposing roles of Shp2 in Myc-driven liver tumor cells and microenvironment is a research paper published in Cell Reports (2021). On theSindex it has a DataRank of 0. It has been cited 49 times.

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Open Access49 citations

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datarank_citation_only_1hop_v6· scope data_onlyMethodology

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Enrichment:Funding (7 grants)Impact (FWCI 3.18)OA: goldTopics (81)IDs (PubMed, PMC, OpenAlex)Annotations (2)

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Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (8)

Yan Liang ORCID,Min Zong,Jacey J. Liu,Kota Kaneko ORCID,Kaisa L. Hanley ORCID

Live enrichment

PubMed:34758313 PMC:PMC8656042 OpenAlex:https://openalex.org/W3214255828

National Cancer Institute

Grant: R01CA236074

National Cancer Institute

Grant: R01CA239629

National Institutes of Health

Grant: T32CA009523

NIDDK NIH HHS

Grant: R01 DK128320

National Institutes of Health

Grant: 5T32CA009523-10

BIOCHEMISTRY OF GROWTH REGULATION AND ONCOGENESIS

National Institutes of Health

Grant: 5R01CA236074-04

Intra- and inter-cellular signals that drive hepato-oncogenesis

National Institutes of Health

Grant: 5R01CA239629-03

Tumor-promoting liver injuries and mechanisms

FWCI

3.18

Citation Percentile

0.9%

Citation Trend

2022

2023

2024

2025

2026

goldLicense: cc-by

journalhttp://www.cell.com/article/S2211124721014534/pdf

publisherhttp://www.cell.com/article/S2211124721014534/pdf

publisherhttps://api.elsevier.com/content/article/PII:S2211124721014534?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S2211124721014534?httpAccept=text/plain

journalhttps://doi.org/10.1016/j.celrep.2021.109974

Fields of Study

Protein Tyrosine PhosphatasesRNA Research and SplicingRNA modifications and cancer0301 basic medicine03 medical and health sciences

MeSH Terms

AnimalsCarcinoma, HepatocellularLiver NeoplasmsMice, Inbred C57BLMutationBiomarkers, TumorGene Expression Regulation, NeoplasticProto-Oncogene Proteins c-mycMice, KnockoutHepatocytesbeta CateninMiceProtein Tyrosine Phosphatase, Non-Receptor Type 11Single-Cell AnalysisTumor MicroenvironmentTranscriptomeWnt Signaling Pathway

Keywords

CarcinogenesisCancer researchWnt signaling pathwayBiologyDownregulation and upregulationMAPK/ERK pathwaySignal transductionTumor microenvironmentHepatocyteTumor progressionCellCell biologyCancerTumor cellsGeneGeneticsIn vitroMacrophagesHepatocellular carcinomaCmycShp2Single Cell Rna SequencingTumor-promoting MicroenvironmentLiver Cancer570Carcinoma, HepatocellularKnockoutChronic Liver Disease and CirrhosisMedical Physiology610Protein Tyrosine Phosphatase, Non-Receptor Type 11Inbred C57BLNon-Receptor Type 11Proto-Oncogene Proteins c-mycMiceRare DiseasesBiomarkers, Tumor2.1 Biological and endogenous factorsAnimalsbeta CateninMice, KnockoutNeoplasticTumorLiver DiseaseCarcinomaLiver NeoplasmsHepatocellularBiological SciencesGene Expression Regulation, NeoplasticMice, Inbred C57BLGene Expression RegulationMutationHepatocytesBiochemistry and Cell BiologyProtein Tyrosine PhosphataseSingle-Cell AnalysisDigestive DiseasesTranscriptomeBiomarkers

Single-cell transcriptomics reveals opposing roles of Shp2 in Myc-driven liver tumor cells and microenvironment

FAIR Checklist

Authors (8)

Funding (7 grants)

Impact

Open Access

Topics

Annotations (Europe PMC)