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Structure-guided changes at the V2 apex of HIV-1 clade C trimer enhance elicitation of autologous neutralizing and broad V1V2-scaffold antibodies

Cell Reports(2022)10.1016/j.celrep.2022.110436Source: DataRank Database

Structure-guided changes at the V2 apex of HIV-1 clade C trimer enhance elicitation of autologous neutralizing and broad V1V2-scaffold antibodies is a research paper published in Cell Reports (2022). On theSindex it has a DataRank of 0.387. It has been cited 9 times, with 2 citing works in its 1-hop citation network.

N/A

0.387DataRank · unranked

Scored on demand from live citation data

Open Access9 citations · 2 citing works in its network

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Linked data & code

gen cellosaurus nct pdb doi

DataRank reads this dataset's downstream impact straight off the citation graph — no black box, no proprietary weighting. How is this computed?

›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (7 grants)Impact (FWCI 0.58)OA: goldTopics (50)IDs (PubMed, PMC, OpenAlex)Annotations (5)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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DataRank Breakdown

Base Score 89%Citation Network 11%

Base Score Contribution

0.345

From this paper's citation signal

Citation Network Contribution

0.0420

From 2 citing papers with measurable signal

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Top 2 citers driving the network score

Ranked by each citer's contribution to N(p) — log1p(C_q) divided by its reference count — out of 2 citers.

Subtle Longitudinal Alterations in Env Sequence Potentiate Differences in Sensitivity to Broadly Neutralizing Antibodies following Acute HIV-1 Subtype C Infection
Journal of Virology20229 citations89 referencesContributes 0.026
Enhancement of Neutralization Responses through Sequential Immunization of Stable Env Trimers Based on Consensus Sequences from Select Time Points by Mimicking Natural Infection
International Journal of Molecular Sciences20233 citations59 referencesContributes 0.023

Authors (15)

Edgar A. Hodge ORCID,Celia C. LaBranche ORCID,Tiffany M. Styles ORCID,Xiaoying Shen ORCID,Narayanaiah Cheedarla ORCID

Live enrichment

PubMed:35235790 PMC:PMC8982139 OpenAlex:https://openalex.org/W4214550493

NIH

Grant: U19 AI109633

NIH

Grant: R01 AI140868

Office of Research Infrastructure Programs, National Institutes of Health

Grant: P51 OD011132

NIH HHS

Grant: U42 OD011023

NIAID NIH HHS

Grant: R01 AI148378

NIH HHS

Grant: U24 OD011023

NIAID NIH HHS

Grant: UM1 AI169662

FWCI

0.58

Citation Percentile

0.7%

Influential Citations

Citation Trend

2022

2023

2025

2026

goldLicense: cc-by-nc-nd

journalhttp://www.cell.com/article/S2211124722001632/pdf

GOLDhttps://doi.org/10.1016/j.celrep.2022.110436

publisherhttp://www.cell.com/article/S2211124722001632/pdf

publisherhttps://api.elsevier.com/content/article/PII:S2211124722001632?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S2211124722001632?httpAccept=text/plain

Fields of Study

HIV Research and TreatmentMonoclonal and Polyclonal Antibodies ResearchRNA and protein synthesis mechanismsMedicineAIDS VaccinesAnimalsAntibodies, NeutralizingHIV AntibodiesHIV AntigensHIV InfectionsHIV SeropositivityHIV-1Rabbitsenv Gene Products, Human Immunodeficiency Virus

MeSH Terms

AnimalsHIV SeropositivityRabbitsHIV AntibodiesHIV AntigensHIV-1HIV InfectionsAIDS Vaccinesenv Gene Products, Human Immunodeficiency VirusAntibodies, Neutralizing

Keywords

Neutralizing antibodyAntibodyTrimerEpitopeScaffoldCladeBiologyVirologyComputational biologyChemistryImmunologyGeneticsGeneMedicinePhylogeneticsImmunogenNeutralizationHiv-1 VaccineAntigenic ProfileBreadthV2 Hotspot173 PositionC.1086 TrimerV1v2 ApexV1v2-scaffold SpecificTime-dependent Bli

Sustainable Development Goals

SDG 0: Good health and well-being