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Disrupted control of origin activation compromises genome integrity upon destabilization of Polε and dysfunction of the TRP53-CDKN1A/P21 axis

Cell Reports(2022)10.1016/j.celrep.2022.110871Source: DataRank Database

Disrupted control of origin activation compromises genome integrity upon destabilization of Polε and dysfunction of the TRP53-CDKN1A/P21 axis is a research paper published in Cell Reports (2022). On theSindex it has a DataRank of 0. It has been cited 7 times.

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Open Access7 citations

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datarank_citation_only_1hop_v6· scope data_onlyMethodology

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Enrichment:Funding (21 grants)Impact (FWCI 0.65)OA: goldTopics (58)IDs (PubMed, PMC, OpenAlex)Annotations (1)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (12)

Stefan Boeing ORCID,Niek van Wietmarschen ORCID,Sriram Sridharan ORCID,Bethany Rebekah Hill,Luigi Ombrato ORCID

Live enrichment

PubMed:35649380 PMC:PMC9637995 OpenAlex:https://openalex.org/W4281678169

Ellison Medical Foundation

Grant: AG-SS- 2633-11

Cancer Research UK

Grant: C7893/A26233

Cancer Research UK

Grant: FC0010048

Royal Society of London for Improving Natural Knowledge

Grant: RGS\\R2\\202163

Cancer Research UK

Grant: 28990

The Francis Crick Institute

Grant: CC1107

The Francis Crick Institute

Grant: CC2057

The Francis Crick Institute

Grant: 10048

Royal Society

Grant: RGS\R2\202163

The Francis Crick Institute

Grant: CC1064

Barts Charity

Grant: MGU0459

Wellcome Trust

Grant: unidentified

unidentified

Ellison Medical Foundation

European Research Council

Medical Research Council

Wellcome Trust

Alex's Lemonade Stand Foundation for Childhood Cancer

Francis Crick Institute

National Institutes of Health

Queen Mary University of London

Wellcome Trust

FWCI

0.65

Citation Percentile

0.7%

Citation Trend

2022

2023

2024

2025

goldLicense: cc-by

journalhttp://www.cell.com/article/S2211124722006465/pdf

publisherhttp://www.cell.com/article/S2211124722006465/pdf

publisherhttps://api.elsevier.com/content/article/PII:S2211124722006465?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S2211124722006465?httpAccept=text/plain

journalhttps://doi.org/10.1016/j.celrep.2022.110871

Fields of Study

Cancer-related Molecular PathwaysMicrotubule and mitosis dynamicsDNA Repair Mechanisms0301 basic medicine0303 health sciences03 medical and health sciencesAnimalsCell Cycle ProteinsCyclin-Dependent Kinase Inhibitor p21DNA DamageDNA Polymerase IIDNA ReplicationMicePoly-ADP-Ribose Binding ProteinsReplication OriginS PhaseTumor Suppressor Protein p53

MeSH Terms

Poly-ADP-Ribose Binding ProteinsAnimalsDNA DamageDNA Polymerase IIDNA ReplicationTumor Suppressor Protein p53S PhaseReplication OriginCell Cycle ProteinsCyclin-Dependent Kinase Inhibitor p21Mice

Keywords

Cell biologyGenomeBiologyGeneticsGeneDNA replicationGenome StabilityTrp53Cdkn1a/p21Cp: Molecular BiologyPolεCyclin-Dependent Kinase Inhibitor p21Model organismsChemical Biology & High ThroughputGenome Integrity & RepairCell Cycle ProteinsReplication OriginDNA Polymerase IITumour BiologyBiochemistry & ProteomicsArticleS PhaseMiceAnimalsCell Cycle & ChromosomesTumor Suppressor Protein p53Poly-ADP-Ribose Binding ProteinsGenetics & GenomicsDNA DamageComputational & Systems Biology

Sustainable Development Goals

SDG 0: Good health and well-being