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Genome-wide CRISPR screen reveals v-ATPase as a drug target to lower levels of ALS protein ataxin-2

Cell Reports(2022)10.1016/j.celrep.2022.111508Source: DataRank Database

Genome-wide CRISPR screen reveals v-ATPase as a drug target to lower levels of ALS protein ataxin-2 is a research paper published in Cell Reports (2022). On theSindex it has a DataRank of 0.870. It has been cited 25 times, with 23 citing works in its 1-hop citation network.

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0.870DataRank · unranked

Scored on demand from live citation data

Deposits data Open Access25 citations · 23 citing works in its network

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Linked data & code

geo uniprot nct

Data availability

Repositories this paper deposited data in (declared in PubMed).

ClinicalTrials.govNCT04494256

DataRank reads this dataset's downstream impact straight off the citation graph — no black box, no proprietary weighting. How is this computed?

›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (20 grants)Impact (FWCI 1.65)OA: goldTopics (61)IDs (PubMed, PMC, OpenAlex)Annotations (3)SDGs (2)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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DataRank Breakdown

Base Score 56%Citation Network 44%

Base Score Contribution

0.489

From this paper's citation signal

Citation Network Contribution

0.382

From 16 citing papers with measurable signal

Learn more about DataRank methodology →

Top 5 citers driving the network score

Ranked by each citer's contribution to N(p) — log1p(C_q) divided by its reference count — out of 23 citers.

Rare association between spinocerebellar ataxia and amyotrophic lateral sclerosis: a case series
Neurological Sciences20247 citations22 referencesContributes 0.095
Regulators of mitonuclear balance link mitochondrial metabolism to mtDNA expression
Nature Cell Biology202341 citations82 referencesContributes 0.046
Chronic suppression of STIM1-mediated calcium signaling in Purkinje cells rescues the cerebellar pathology in spinocerebellar ataxia type 2
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research202316 citations63 referencesContributes 0.045
Modeling sporadic juvenile ALS in iPSC-derived motor neurons explores the pathogenesis of FUSR503fs mutation
Frontiers in Cellular Neuroscience20242 citations28 referencesContributes 0.039
ATP6V1A is required for synaptic rearrangements and plasticity in murine hippocampal neurons
Acta Physiologica20246 citations54 referencesContributes 0.036

Authors (11)

Lisa Nakayama ORCID,Jacob A. Blum ORCID,Tetsuya Akiyama ORCID,Steven Boeynaems ORCID,Meenakshi Chakraborty ORCID

Live enrichment

PubMed:36288714 PMC:PMC9664452 OpenAlex:https://openalex.org/W4307584736

Maze Therapeutics

Grant: 63/286,436

National Institute of Diabetes and Digestive and Kidney Diseases

Grant: P30DK116074

NIA NIH HHS

Grant: R01 AG064690

NIA NIH HHS

Grant: RF1 AG064690

Takeda Science Foundation

Grant: S10OD025212

NIA NIH HHS

Grant: T32 AG047126

NIMH NIH HHS

Grant: T32 MH020016

NINDS NIH HHS

Grant: F31 NS125681

NINDS NIH HHS

Grant: F32 NS116208

NINDS

Grant: R35NS097263

National Institutes of Health

Grant: 1F31NS125681-01

A Novel Genome-Wide Screen to Identify and Characterize Regulators of ALS Disease Modifier Gene Ataxin-2

National Institutes of Health

Grant: 2T32AG047126-06A1

Stanford Training Program in Aging Research

National Institutes of Health

Grant: 1S10OD025212-01

Ultra high throughput sequencer for sustaining and enhancing multi-scale genomic studies

National Institutes of Health

Grant: 3R35NS097263-06S1

Innovating Yeast and Human Genetics Approaches to Define Mechanisms of Neurodegenerative Disease

National Institutes of Health

Grant: 5F32NS116208-02

Deciphering the role of Ataxin-2 in amyotrophic lateral sclerosis

National Institutes of Health

Grant: 5P30DK116074-04

Stanford Diabetes Research Center

National Institutes of Health

Grant: 2R01AG064690-02

Defining modifiers and mechanisms of RAN translation

Robert Packard Center for ALS Research, Johns Hopkins University

Stanford University

National Institutes of Health

FWCI

1.65

Citation Percentile

0.8%

Citation Trend

2022

2023

2024

2025

2026

goldLicense: cc-by

journalhttps://doi.org/10.1016/j.celrep.2022.111508

publisherhttps://doi.org/10.1016/j.celrep.2022.111508

repositoryhttps://pubmed.ncbi.nlm.nih.gov/36288714

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/9664452

Europe_PMChttps://europepmc.org/articles/PMC9664452

Fields of Study

Mitochondrial Function and PathologyAmyotrophic Lateral Sclerosis ResearchGenetic Neurodegenerative Diseases0301 basic medicine0303 health sciences03 medical and health sciencesAnimalsHumansMiceAtaxin-2Amyotrophic Lateral SclerosisVacuolar Proton-Translocating ATPasesPharmaceutical PreparationsEtidronic AcidSpinocerebellar AtaxiasOligonucleotides, Antisense

MeSH Terms

Ataxin-2Amyotrophic Lateral SclerosisAnimalsPharmaceutical PreparationsHumansEtidronic AcidOligonucleotides, AntisenseSpinocerebellar AtaxiasVacuolar Proton-Translocating ATPasesMice

Keywords

Spinocerebellar ataxiaBiologyDruggabilityGeneAmyotrophic lateral sclerosisCRISPRATPaseCell biologyDrug discoveryGeneticsComputational biologyBiochemistryDiseaseEnzymeMedicineV-ATPaseFACSALSBisphosphonateTdp-43EtidronateSca2Ataxin-2Genetic ScreensSmall-molecule TherapyCp: NeuroscienceVacuolar Proton-Translocating ATPasesEtidronic AcidOligonucleotides, AntisenseArticleMicePharmaceutical PreparationsAnimalsHumansSpinocerebellar Ataxias

Sustainable Development Goals

SDG 3: 3. Good healthSDG 0: Good health and well-being

Genome-wide CRISPR screen reveals v-ATPase as a drug target to lower levels of ALS protein ataxin-2

FAIR Checklist

DataRank Breakdown

Top 5 citers driving the network score

Authors (11)

Funding (20 grants)

Impact

Open Access

Topics

Annotations (Europe PMC)