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Interpretable deep learning translation of GWAS and multi-omics findings to identify pathobiology and drug repurposing in Alzheimer’s disease

Cell Reports(2022)10.1016/j.celrep.2022.111717Source: DataRank Database

Interpretable deep learning translation of GWAS and multi-omics findings to identify pathobiology and drug repurposing in Alzheimer’s disease is a research paper published in Cell Reports (2022). On theSindex it has a DataRank of 0. It has been cited 106 times.

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Scored on demand from live citation data

Open Access106 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (28 grants)Impact (FWCI 6.50)OA: goldTopics (56)IDs (PubMed, PMC, OpenAlex)Annotations (4)SDGs (2)

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Findable (1/2)

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Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (17)

Chengsheng Mao ORCID,Yuan Hou,Yuan Luo ORCID,Jessica Binder ORCID,Yadi Zhou ORCID

Live enrichment

PubMed:36450252 PMC:PMC9837836 OpenAlex:https://openalex.org/W4310701303

National Institute of General Medical Sciences

Grant: P20GM109025

National Institute of Neurological Disorders and Stroke

Grant: R01AG053798

National Institute of Neurological Disorders and Stroke

Grant: R35AG071476

National Institute of Neurological Disorders and Stroke

Grant: U01NS093334

National Institute on Aging

Grant: P30AG072959

National Institute on Aging

Grant: 3R01AG066707-01S1

Endophenotype Network-based Approaches to Prediction and Population-based Validation of in Silico Drug Repurposing for Alzheimer's Disease

National Institute on Aging

Grant: R01AG076448

National Institute on Aging

Grant: R56AG074001

National Institute on Aging

Grant: U01AG073323

NIA NIH HHS

Grant: R01 AG066707

NIA NIH HHS

Grant: U24 AG021886

NIA NIH HHS

Grant: K08 AG065463

NCATS NIH HHS

Grant: UL1 TR001422

NIA NIH HHS

Grant: P30 AG072977

National Institutes of Health

Grant: 5P20GM109025-03

COBRE GRANT

National Institutes of Health

Grant: 5U01AG073323-05

Alzheimer's MultiOme Data Repurposing: Artificial Intelligence, Network Medicine, and Therapeutics Discovery

National Institutes of Health

Grant: 5R01AG076448-03

TREM2 Genotype-Informed Drug Repurposing and Combination Therapy Design for Alzheimers Disease

National Institutes of Health

Grant: 1R56AG074001-01

Multimodal single-cell genomic and epigenomic analyses elucidate Alzheimer’s sexual dimorphism in human immune systems aging

National Institutes of Health

Grant: 5U01NS093334-02

Chronic Traumatic Encephalopathy: Detection, Diagnosis, Course, and Risk Factors

National Institutes of Health

Grant: 5R01AG053798-02

Global Alzheimer's Platform Trial-Ready Cohort for Preclinical/Prodromal Alzheimer's Disease

National Institutes of Health

Grant: 5R35AG071476-02

Alzheimer's Clinical Trial InnOvatioN (ACTION) Initiative

National Institutes of Health

Grant: 5P30AG072959-02

Cleveland Alzheimers Disease Research Center

Foundation for the National Institutes of Health

Alzheimer's Drug Discovery Foundation

Brockman Foundation

GE Healthcare

National Institutes of Health

Novo Nordisk

FWCI

6.50

Citation Percentile

1.0%

Citation Trend

2023

2024

2025

2026

goldLicense: CC BY NC ND

journalhttps://doi.org/10.1016/j.celrep.2022.111717

publisherhttps://doi.org/10.1016/j.celrep.2022.111717

publisherhttps://api.elsevier.com/content/article/PII:S2211124722015959?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S2211124722015959?httpAccept=text/plain

repositoryhttps://pubmed.ncbi.nlm.nih.gov/36450252

Fields of Study

Bioinformatics and Genomic NetworksGenetic Associations and EpidemiologyAlzheimer's disease research and treatments0301 basic medicine0303 health sciences03 medical and health sciencesHumansGenome-Wide Association StudyDrug RepositioningAlzheimer DiseaseDeep LearningGemfibrozilRetrospective Studies

MeSH Terms

Deep LearningAlzheimer DiseaseHumansRetrospective StudiesGemfibrozilGenome-Wide Association StudyDrug Repositioning

Keywords

Genome-wide association studyDrug repositioningBiologyComputational biologyRepurposingPSEN1GemfibrozilGenomicsDiseaseGeneticsBioinformaticsSingle-nucleotide polymorphismGenomeMedicineGeneDrugAlzheimer's diseasePharmacologyInternal medicineDrug targetAlzheimer’s diseaseADPathobiologyGenome-wide Association StudiesGwasEhrElectronic Health RecordDrug RepurposingDeep LearningMulti-omicsProtein-protein InteractomeCp: NeuroscienceAlzheimer DiseaseHumansArticleRetrospective Studies

Sustainable Development Goals

SDG 3: 3. Good healthSDG 0: Good health and well-being