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AKT activation because of PTEN loss upregulates xCT via GSK3β/NRF2, leading to inhibition of ferroptosis in PTEN-mutant tumor cells

Cell Reports(2023)10.1016/j.celrep.2023.112536Source: DataRank Database

AKT activation because of PTEN loss upregulates xCT via GSK3β/NRF2, leading to inhibition of ferroptosis in PTEN-mutant tumor cells is a research paper published in Cell Reports (2023). On theSindex it has a DataRank of 0. It has been cited 51 times.

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0DataRank · unranked

Scored on demand from live citation data

Open Access51 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (5 grants)Impact (FWCI 8.58)OA: goldTopics (53)IDs (PubMed, OpenAlex)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (9)

Abigail Lubin ORCID,Kaitlyn Bosch ORCID,Nicole Stokes,Sarah Mense Shoenfeld,Royce Zhou ORCID

Live enrichment

PubMed:37210723 OpenAlex:https://openalex.org/W4377157427

National Cancer Institute

Grant: R35CA220491

University of California, San Diego

Grant: SLC7A11

National Institutes of Health

Grant: 3R35CA220491-02S1

PTEN and Cancer

National Institutes of Health

Grant: 1P30CA196521-01

Mouse Genetics

NCI NIH HHS

Grant: P30 CA196521

FWCI

8.58

Citation Percentile

1.0%

Citation Trend

2023

2024

2025

2026

goldLicense: cc-by-nc-nd

journalhttp://www.cell.com/article/S2211124723005478/pdf

publisherhttp://www.cell.com/article/S2211124723005478/pdf

publisherhttps://api.elsevier.com/content/article/PII:S2211124723005478?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S2211124723005478?httpAccept=text/plain

journalhttps://doi.org/10.1016/j.celrep.2023.112536

Fields of Study

Ferroptosis and cancer prognosisCancer-related molecular mechanisms researchCancer, Lipids, and Metabolism0301 basic medicine03 medical and health sciencesAnimalsMiceCystineProto-Oncogene Proteins c-aktNF-E2-Related Factor 2FerroptosisGlycogen Synthase Kinase 3 betaFibroblasts

MeSH Terms

Glycogen Synthase Kinase 3 betaFerroptosisAnimalsCystineFibroblastsProto-Oncogene Proteins c-aktNF-E2-Related Factor 2Mice

Keywords

PTENProtein kinase BMutantCancer researchChemistryCell biologyPI3K/AKT/mTOR pathwayPhosphorylationSignal transductionBiologyBiochemistryGeneGlycogen Synthase Kinase 3 betaQH301-705.5NF-E2-Related Factor 2FibroblastsCP: MetabolismArticleMiceAnimalsCystineFerroptosisBiology (General)CP: CancerProto-Oncogene Proteins c-aktAktGSK3βNRF2cancercysteineglutathionexCT

Sustainable Development Goals

SDG 0: Good health and well-being