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Therapeutic targeting of immunometabolism reveals a critical reliance on hexokinase 2 dosage for microglial activation and Alzheimer’s progression

Cell Reports(2024)10.1016/j.celrep.2024.114488Source: DataRank Database

Therapeutic targeting of immunometabolism reveals a critical reliance on hexokinase 2 dosage for microglial activation and Alzheimer’s progression is a research paper published in Cell Reports (2024). On theSindex it has a DataRank of 0. It has been cited 35 times.

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0DataRank · unranked

Scored on demand from live citation data

Open Access35 citations

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Linked data & code

geo gen uniprot doi

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (7 grants)Impact (FWCI 6.74)OA: goldTopics (57)IDs (PubMed, PMC, OpenAlex)Annotations (4)SDGs (2)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (10)

Claudia Mera-Reina,Peter Bor‐Chian Lin ORCID,Paul B Fallen,Shweta S. Puntambekar,Brad T. Casali ORCID

Live enrichment

PubMed:39002124 PMC:PMC11398604 OpenAlex:https://openalex.org/W4400606023

National Institutes of Health

Grant: RF1AG068400

CTSI

Grant: EPAR1536

School of Medicine, Indiana University

Grant: P30 CA082709

BrightFocus Foundation

Grant: A20201166F

National Institutes of Health

Grant: 1RF1AG068400-01

Microglial hexokinase 2 as a therapeutic target in Alzheimer's disease

National Institutes of Health

Grant: 3P30CA082709-16S3

Indiana University Melvin and Bren Simon Cancer Center Support Grant

University of Illinois College of Medicine

FWCI

6.74

Citation Percentile

1.0%

Citation Trend

2024

2025

2026

goldLicense: CC BY NC ND

journalhttps://doi.org/10.1016/j.celrep.2024.114488

publisherhttps://doi.org/10.1016/j.celrep.2024.114488

publisherhttps://api.elsevier.com/content/article/PII:S2211124724008179?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S2211124724008179?httpAccept=text/plain

repositoryhttps://pubmed.ncbi.nlm.nih.gov/39002124

Fields of Study

Neuroinflammation and Neurodegeneration MechanismsImmune cells in cancerTryptophan and brain disorders0301 basic medicine03 medical and health sciences0303 health sciences

MeSH Terms

NF-KappaB Inhibitor alphaAlzheimer DiseaseAnimalsBrainGlycolysisHexokinaseHumansInflammationMice, TransgenicMitochondriaSignal TransductionNF-kappa BMicrogliaDisease ProgressionGene DosageMice

Keywords

HexokinaseMicrogliaBiologyMedicinePharmacologyGlycolysisImmunologyInflammationEnzymeBiochemistryMitochondriaAmyloidNF-κBAlzheimer’s diseaseHexokinase 2LonidamineCp: NeuroscienceCp: MetabolismQH301-705.5Gene Dosage610Mice, TransgenicArticleMiceNF-KappaB Inhibitor alphaAlzheimer DiseaseAnimalsHumansBiology (General)NF-kappa BBrainMetabolismDisease ProgressionNeuroscienceSignal Transduction

Sustainable Development Goals

SDG 3: 3. Good healthSDG 0: Zero hunger