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The TRIM4 E3 ubiquitin ligase degrades TPL2 and is modulated by oncogenic KRAS

Cell Reports(2024)10.1016/j.celrep.2024.114667Source: DataRank Database

The TRIM4 E3 ubiquitin ligase degrades TPL2 and is modulated by oncogenic KRAS is a research paper published in Cell Reports (2024). On theSindex it has a DataRank of 0. It has been cited 3 times.

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Open Access3 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (12 grants)Impact (FWCI 0.48)OA: goldTopics (66)IDs (PubMed, PMC, OpenAlex)Annotations (3)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (11)

Paarth B. Dodhiawala ORCID,Yutong Geng,Ashenafi Bulle ORCID,Peng Liu ORCID,Lin Li ORCID

Live enrichment

PubMed:39178114 PMC:PMC11472288 OpenAlex:https://openalex.org/W4401814714

NCI NIH HHS

Grant: P30 CA091842

NCI NIH HHS

Grant: R00 CA248495

NCATS NIH HHS

Grant: UL1 TR000448

NCI NIH HHS

Grant: R37 CA219697

NIGMS NIH HHS

Grant: R24 GM136766

NCI NIH HHS

Grant: R01 CA262414

NIGMS NIH HHS

Grant: P41 GM103422

NCATS NIH HHS

Grant: UL1 TR002345

NCATS

Alvin J Siteman Cancer Center

NIGMS

NCI

FWCI

0.48

Citation Percentile

0.6%

Citation Trend

2025

2026

goldLicense: cc-by-nc

journalhttp://www.cell.com/article/S2211124724010180/pdf

publisherhttp://www.cell.com/article/S2211124724010180/pdf

publisherhttps://api.elsevier.com/content/article/PII:S2211124724010180?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S2211124724010180?httpAccept=text/plain

journalhttps://doi.org/10.1016/j.celrep.2024.114667

Fields of Study

Ubiquitin and proteasome pathwaysinterferon and immune responsesImmune Cell Function and InteractionAnimalsHumansbeta CateninCell Line, TumorGlycogen Synthase Kinase 3 betaHEK293 CellsMutationPhosphorylationProtein BindingProteolysisProto-Oncogene ProteinsProto-Oncogene Proteins p21(ras)RibonucleoproteinsUbiquitin-Protein LigasesUbiquitinationWnt Signaling PathwaySS-A AntigenMAP Kinase Kinase KinasesTripartite Motif Proteins

MeSH Terms

Tripartite Motif ProteinsGlycogen Synthase Kinase 3 betaSS-A AntigenAnimalsHumansMutationPhosphorylationProtein BindingProto-Oncogene ProteinsRibonucleoproteinsProto-Oncogene Proteins p21(ras)MAP Kinase Kinase KinasesUbiquitin-Protein LigasesCell Line, Tumorbeta CateninUbiquitinationHEK293 CellsProteolysisWnt Signaling Pathway

Keywords

Ubiquitin ligaseUbiquitinKRASDNA ligaseCell biologyUbiquitin-Protein LigasesComputational biologyChemistryBioinformaticsCancer researchBiologyGeneticsMutationGeneUbiquitinationProtein degradationWnt/β-cateninTpl2CotMap3k8Trim4Trim21Rnf185Cp: Molecular BiologyCp: Cancer

The TRIM4 E3 ubiquitin ligase degrades TPL2 and is modulated by oncogenic KRAS

FAIR Checklist

Authors (11)

Funding (12 grants)

Impact

Open Access

Topics

Annotations (Europe PMC)