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HIRA protects telomeres against R-loop-induced instability in ALT cancer cells

Cell Reports(2024)10.1016/j.celrep.2024.114964Source: DataRank Database

HIRA protects telomeres against R-loop-induced instability in ALT cancer cells is a research paper published in Cell Reports (2024). On theSindex it has a DataRank of 0.647. It has been cited 22 times, with 21 citing works in its 1-hop citation network.

N/A

0.647DataRank · unranked

Scored on demand from live citation data

Deposits data Open Access22 citations · 21 citing works in its network

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Linked data & code

geo gen cellosaurus uniprot

Data availability

Repositories this paper deposited data in (declared in PubMed).

GEOGSE269261 GSE269268

DataRank reads this dataset's downstream impact straight off the citation graph — no black box, no proprietary weighting. How is this computed?

›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (13 grants)OA: goldTopics (22)IDs (PubMed, PMC)Annotations (4)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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DataRank Breakdown

Base Score 73%Citation Network 27%

Base Score Contribution

0.470

From this paper's citation signal

Citation Network Contribution

0.177

From 10 citing papers with measurable signal

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Top 5 citers driving the network score

Ranked by each citer's contribution to N(p) — log1p(C_q) divided by its reference count — out of 21 citers.

Oxidative stress at telomeres triggers internal DNA loops, TRF1 dissociation, and TRF2-dependent R-loops
Nucleic Acids Research202512 citations51 referencesContributes 0.050
R-loop homeostasis in genome dynamics, gene expression and development
Current Opinion in Genetics & Development202515 citations83 referencesContributes 0.033
Identification of modulators of the ALT pathway through a native FISH-based optical screen
Cell Reports202413 citations106 referencesContributes 0.025
Conserved and unique features of terminal telomeric sequences in ALT-positive cancer cells
eLife20253 citations58 referencesContributes 0.024
Transcription‐Replication Conflicts: Unlocking New Frontiers in Cancer
BioEssays20256 citations108 referencesContributes 0.018

Authors (12)

Emily Brown ORCID,Ragini Bhargava,Anne R. Wondisford,Jean-Baptiste Ouriou,Oliver Freund

Live enrichment

PubMed:39509271 PMC:PMC11698518

NCI NIH HHS

Grant: R01 CA262316

NIH HHS

Grant: S10 OD028483

NIGMS NIH HHS

Grant: R35 GM133732

NIBIB NIH HHS

Grant: T32 EB001026

NCI NIH HHS

Grant: F30 CA278287

NCI NIH HHS

Grant: P30 CA047904

NCI NIH HHS

Grant: R01 CA207209

NCI NIH HHS

Grant: R37 CA263622

Université Pierre et Marie Curie

National Institute of General Medical Sciences

Israel National Road Safety Authority

National Cancer Institute

National Institutes of Health

goldLicense: cc-by-nc-nd

publisherhttps://doi.org/10.1016/j.celrep.2024.114964

publisherhttps://api.elsevier.com/content/article/PII:S2211124724013159?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S2211124724013159?httpAccept=text/plain

repositoryhttps://pmc.ncbi.nlm.nih.gov/articles/PMC11698518/pdf/nihms-2041681.pdf

Europe_PMChttps://europepmc.org/articles/PMC11698518

MeSH Terms

Cell Line, TumorChromatinTelomereHumansNeoplasmsCell Cycle ProteinsMolecular ChaperonesHistonesTranscription FactorsHistone ChaperonesCo-Repressor ProteinsTelomere HomeostasisX-linked Nuclear ProteinR-Loop Structures

Keywords

CancerHistoneTelomereALTR-loopHiraCp: Molecular BiologyCp: Cancer