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Dual α-globin-truncated erythropoietin receptor knockin restores hemoglobin production in α-thalassemia-derived erythroid cells

Cell Reports(2025)10.1016/j.celrep.2024.115141Source: DataRank Database

Dual α-globin-truncated erythropoietin receptor knockin restores hemoglobin production in α-thalassemia-derived erythroid cells is a research paper published in Cell Reports (2025). On theSindex it has a DataRank of 0.399. It has been cited 11 times, with 6 citing works in its 1-hop citation network.

N/A

0.399DataRank · unranked

Scored on demand from live citation data

Deposits data Open Access11 citations · 6 citing works in its network

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Data availability

Repositories this paper deposited data in (declared in PubMed).

SRAPRJNA1193132

DataRank reads this dataset's downstream impact straight off the citation graph — no black box, no proprietary weighting. How is this computed?

›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (16 grants)Impact (FWCI 8.65)OA: goldTopics (82)IDs (PubMed, OpenAlex)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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DataRank Breakdown

Base Score 93%Citation Network 7%

Base Score Contribution

0.373

From this paper's citation signal

Citation Network Contribution

0.0264

From 3 citing papers with measurable signal

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Top 5 citers driving the network score

Ranked by each citer's contribution to N(p) — log1p(C_q) divided by its reference count — out of 6 citers.

Screening and treatment of thalassemia
Clinica Chimica Acta202513 citations121 referencesContributes 0.022
Engineering strategies for microbial synthesis, customized modification, and application of hemoglobin
Biotechnology Advances20253 citations228 referencesContributes 0.006
Integrating synthetic biology to understand and engineer the heart, lung, blood, and sleep systems
Cell Systems20251 citations217 referencesContributes 0.003
CRISPR in Thalassemia: Global Research Trend Analysis
Hemoglobin20260 citations74 referencesContributes 0.000
In vitro and in vivo base editing of CCR5 in hematopoietic stem cells confers HIV-1 resistance
Molecular Therapy20260 citations70 referencesContributes 0.000

Authors (25)

Eric Soupène ORCID,Devesh Sharma ORCID,Roshani Sinha ORCID,Travis McCreary ORCID,Britney Hernandez ORCID

Live enrichment

PubMed:39754719 OpenAlex:https://openalex.org/W4406070839

California Institute for Regenerative Medicine

Grant: INFR6.2-15527

National Institutes of Health

Grant: R01-HL161291

National Institutes of Health

Grant: P01-HL146366

National Institutes of Health

Grant: R01-HL130533

National Institutes of Health

Grant: R01-HL13535801

National Institutes of Health

Grant: R01-AG072052

National Institutes of Health

Grant: 5R01AG072052-03

C9orf72 frontotemporal dementia (FTD) and amyotrophic lateral sclerosis(ALS): using patient cells and CRISPR to reveal therapeutic approaches

National Institutes of Health

Grant: 1R01HL161291-01

Developing gene therapy strategies to treat alpha thalassemia

National Institutes of Health

Grant: 5P01HL146366-04

Combinatorial Regulation of Gene Networks During Cardiac Development and Disease

National Institutes of Health

Grant: 1R01HL130533-01

Identifying Therapeutic Targets for RNA Splicing-Related Cardiomyopathy

NIAID NIH HHS

Grant: T32 AI125222

NHLBI NIH HHS

Grant: R01 HL130533

NIA NIH HHS

Grant: R01 AG072052

NHLBI NIH HHS

Grant: P01 HL146366

NHLBI NIH HHS

Grant: R01 HL161291

NHLBI NIH HHS

Grant: R01 HL135358

FWCI

8.65

Citation Percentile

1.0%

Citation Trend

2025

2026

goldLicense: cc-by-nc-nd

journalhttps://doi.org/10.1016/j.celrep.2024.115141

publisherhttps://doi.org/10.1016/j.celrep.2024.115141

publisherhttps://api.elsevier.com/content/article/PII:S221112472401492X?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S221112472401492X?httpAccept=text/plain

repositoryhttps://pubmed.ncbi.nlm.nih.gov/39754719

Fields of Study

Hemoglobinopathies and Related DisordersErythrocyte Function and PathophysiologyIron Metabolism and Disorders03 medical and health sciences0303 health sciencesHumansalpha-GlobinsErythroid CellsReceptors, Erythropoietinalpha-ThalassemiaHemoglobinsGene EditingHematopoietic Stem CellsGene Knock-In Techniquesbeta-GlobinsErythropoiesisCRISPR-Cas Systems

MeSH Terms

Gene EditingErythropoiesisHematopoietic Stem CellsHemoglobinsHumansalpha-ThalassemiaReceptors, ErythropoietinErythroid Cellsalpha-Globinsbeta-GlobinsGene Knock-In TechniquesCRISPR-Cas Systems

Keywords

ErythropoietinThalassemiaGlobinHemoglobinErythropoietin receptorReceptorErythropoiesisBiologyCell biologyInternal medicineEndocrinologyChemistryAnemiaMedicineGenetics570QH301-705.5hematopoietic stem and progenitor cellsMedical Physiology610adeno-associated virusbeta-GlobinsRegenerative MedicineArticleHemoglobinsRare DiseasesCP: Stem cell researchalpha-GlobinsErythroid Cellsalpha-ThalassemiaStem Cell Research - Nonembryonic - HumanReceptors, Erythropoietingenome editingHumansGene Knock-In TechniquesBiology (General)Gene EditingTransplantationSickle Cell DiseaseCooley's AnemiaRNA sequencingHematologyBiological SciencesStem Cell ResearchHematopoietic Stem CellsBloodCRISPRα-thalassemiaStem Cell Research - Nonembryonic - Non-HumanBiochemistry and Cell BiologyCRISPR-Cas SystemsBiotechnologyred blood cells

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