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IL-21 shapes the B cell response in a context-dependent manner

Cell Reports(2025)10.1016/j.celrep.2024.115190Source: DataRank Database

IL-21 shapes the B cell response in a context-dependent manner is a research paper published in Cell Reports (2025). On theSindex it has a DataRank of 0.526. It has been cited 19 times, with 17 citing works in its 1-hop citation network.

N/A

0.526DataRank · unranked

Scored on demand from live citation data

Deposits data Open Access19 citations · 17 citing works in its network

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Linked data & code

geo cellosaurus

Data availability

Repositories this paper deposited data in (declared in PubMed).

GEOGSE280837 GSE280838

DataRank reads this dataset's downstream impact straight off the citation graph — no black box, no proprietary weighting. How is this computed?

›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (10 grants)Impact (FWCI 7.96)OA: goldTopics (29)IDs (PubMed, PMC, OpenAlex)Annotations (2)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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DataRank Breakdown

Base Score 85%Citation Network 15%

Base Score Contribution

0.449

From this paper's citation signal

Citation Network Contribution

0.0770

From 9 citing papers with measurable signal

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Top 5 citers driving the network score

Ranked by each citer's contribution to N(p) — log1p(C_q) divided by its reference count — out of 17 citers.

T Peripheral Helper Cells in Lymphoid Aggregate and Tertiary Lymphoid Structure Formation
Immunological Reviews20255 citations114 referencesContributes 0.016
Reprogramming natural killer cells in the tumor microenvironment: Challenges and therapeutic opportunities
Cytokine & Growth Factor Reviews202511 citations163 referencesContributes 0.015
Single‐Target Pairing System (StarPair) for Large‐Scale Interrogation of Cell–Cell Interactions
Advanced Science20251 citations51 referencesContributes 0.014
Longitudinal Monitoring of Systemic Cytokines After Mild Zika Virus Infection Revealed an Association Between Th17 Polarization and Clinical and Serological Outcomes
Journal of Medical Virology20261 citations51 referencesContributes 0.014
The dual immunomodulatory role of B cells in tumorigenesis: mechanisms, microenvironment crosstalk, and therapeutic implications
Frontiers in Immunology20254 citations161 referencesContributes 0.010

Authors (10)

Francesca Manara,Simon Grassmann ORCID,Kalina T. Belcheva,Kanelly Reyes,Hyunu Kim ORCID

Live enrichment

PubMed:39792552 PMC:PMC11973891 OpenAlex:https://openalex.org/W4406218814

NCI

Grant: P30CA008748

Cancer Research Institute

Grant: K99AI180360

National Institutes of Health National Institute of Allergy and Infectious Diseases

Grant: R01AI072194

National Institutes of Health National Institute of Allergy and Infectious Diseases

Grant: R01AI124186

NCI NIH HHS

Grant: K08 CA259533

Marie-Josée and Henry R. Kravis Center for Molecular Oncology

American-Italian Cancer Foundation

Tower Cancer Research Foundation

Cycle for Survival

National Institutes of Health

FWCI

7.96

Citation Percentile

1.0%

Citation Trend

2025

2026

goldLicense: cc-by

journalhttps://doi.org/10.1016/j.celrep.2024.115190

publisherhttps://doi.org/10.1016/j.celrep.2024.115190

publisherhttps://api.elsevier.com/content/article/PII:S2211124724015419?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S2211124724015419?httpAccept=text/plain

repositoryhttps://pubmed.ncbi.nlm.nih.gov/39792552

Fields of Study

T-cell and B-cell ImmunologyImmune Cell Function and InteractionImmunotherapy and Immune Responses

MeSH Terms

Interleukin-21AnimalsB-LymphocytesImmunoglobulin GInterleukinsLymphocyte ActivationMice, Inbred C57BLPlasma CellsApoptosisMice, KnockoutGerminal CenterCell ProliferationSTAT3 Transcription FactorMiceReceptors, Interleukin-21Interleukin-21 Receptor alpha Subunit

Keywords

Context (archaeology)Cell biologyBiologyB cellHumoral immunityIl-21Somatic HypermutationGerminal CentersClass-switchingCp: Immunology