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SIRT2 suppresses aging-associated cGAS activation and protects aged mice from severe COVID-19

Cell Reports(2025)10.1016/j.celrep.2025.115562Source: DataRank Database

SIRT2 suppresses aging-associated cGAS activation and protects aged mice from severe COVID-19 is a research paper published in Cell Reports (2025). On theSindex it has a DataRank of 0. It has been cited 10 times.

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Open Access10 citations

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Enrichment:Funding (10 grants)Impact (FWCI 4.02)OA: goldTopics (62)IDs (PubMed, PMC, OpenAlex)Annotations (1)SDGs (1)

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Findable (1/2)

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Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (16)

Biyun Xue,Jian Zheng ORCID,Yifei Wang ORCID,Zehan Song ORCID,Wei‐Chieh Mu ORCID

Live enrichment

PubMed:40220296 PMC:PMC12074670 OpenAlex:https://openalex.org/W4409349454

National Institute of Diabetes and Digestive and Kidney Diseases

Grant: R01DK 117481

National Institute of Allergy and Infectious Diseases Division of Intramural Research

Grant: R01 AI129269

National Institute of Allergy and Infectious Diseases Division of Intramural Research

Grant: P01AI060699

National Institute on Aging

Grant: R01AG082105

National Institute on Aging

Grant: R01AG063404

National Institute on Aging

Grant: R01AG 063389

National Institute of Food and Agriculture

American Foundation for Aging Research

California Institute for Regenerative Medicine

National Institutes of Health

FWCI

4.02

Citation Percentile

0.9%

Citation Trend

2025

2026

goldLicense: cc-by

journalhttps://doi.org/10.1016/j.celrep.2025.115562

publisherhttps://doi.org/10.1016/j.celrep.2025.115562

publisherhttps://api.elsevier.com/content/article/PII:S221112472500333X?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S221112472500333X?httpAccept=text/plain

repositoryhttps://pubmed.ncbi.nlm.nih.gov/40220296

Fields of Study

interferon and immune responsesInflammasome and immune disordersCytomegalovirus and herpesvirus researchAnimalsCOVID-19AgingNucleotidyltransferasesMiceSirtuin 2SARS-CoV-2Mice, Inbred C57BLMice, KnockoutHumansNADAcetylationDNA, MitochondrialMaleInflammationCyclic Guanosine Monophosphate-Adenosine Monophosphate Synthase

MeSH Terms

COVID-19SARS-CoV-2Cyclic Guanosine Monophosphate-Adenosine Monophosphate SynthaseAcetylationAgingAnimalsDNA, MitochondrialHumansInflammationMaleMice, Inbred C57BLNADNucleotidyltransferasesMice, KnockoutMiceSirtuin 2

Keywords

Coronavirus disease 2019 (COVID-19)SIRT2Virology2019-20 coronavirus outbreakSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)BiologyCell biologyMedicineGeneticsGeneInternal medicineSirtuinOutbreakMitochondriaAgingInflammationSIRT1NadSirt3Sirt6Sirt7CgasOrf3aCovid-19Sars-cov-2Cp: ImmunologyCp: Microbiology

Sustainable Development Goals

SDG 0: Zero hunger

SIRT2 suppresses aging-associated cGAS activation and protects aged mice from severe COVID-19

FAIR Checklist

Authors (16)

Funding (10 grants)

Impact

Open Access

Topics

Annotations (Europe PMC)