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Circuit-selective pharmacological targeting of prefrontal cortex-projecting locus coeruleus neurons drives antinociception

Cell Reports(2025)10.1016/j.celrep.2025.116294Source: DataRank Database

Circuit-selective pharmacological targeting of prefrontal cortex-projecting locus coeruleus neurons drives antinociception is a research paper published in Cell Reports (2025). On theSindex it has a DataRank of 0.

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Enrichment:Funding (7 grants)Impact (FWCI 0.00)OA: goldTopics (32)IDs (PubMed, PMC, OpenAlex)Annotations (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (2)

Jordan G. McCall ORCID,Chao‐Cheng Kuo ORCID

Live enrichment

PubMed:40971298 PMC:PMC12967295 OpenAlex:https://openalex.org/W4414380320

National Institute of Neurological Disorders and Stroke

Grant: R01NS117899

National Institute of Neurological Disorders and Stroke

Grant: R01NS135401

National Institute on Drug Abuse

Grant: R21DA060414

National Institutes of Health

Washington University in Saint Louis McDonnell Center for Systems Neuroscience

Open Philanthropy Project

Rita Allen Foundation

FWCI

0.00

Citation Percentile

0.2%

goldLicense: cc-by-nc-nd

journalhttps://doi.org/10.1016/j.celrep.2025.116294

publisherhttps://doi.org/10.1016/j.celrep.2025.116294

publisherhttps://api.elsevier.com/content/article/PII:S2211124725010654?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S2211124725010654?httpAccept=text/plain

repositoryhttps://pubmed.ncbi.nlm.nih.gov/40971298

Fields of Study

Nicotinic Acetylcholine Receptors StudyNeuroscience and Neuropharmacology ResearchPain Mechanisms and Treatments

MeSH Terms

Action PotentialsAnalgesicsAnimalsLocus CoeruleusMaleMice, Inbred C57BLNeuronsPrefrontal CortexReceptors, G-Protein-CoupledMiceNociceptionOptogenetics

Keywords

Locus coeruleusOptogeneticsEfferentAgonistBiological neural networkEndogenyPrefrontal cortexNeuromodulationNorepinephrineserotonin receptorsmuscarinic receptorsOpioid receptorsCalcium imagingAntinociceptionGpcrSpike DeconvolutionCp: Neuroscience

Circuit-selective pharmacological targeting of prefrontal cortex-projecting locus coeruleus neurons drives antinociception

FAIR Checklist

Authors (2)

Funding (7 grants)

Impact

Open Access

Topics

Annotations (Europe PMC)