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Aromatic microbial metabolite hippuric acid enhances inflammatory responses in macrophages via TLR-MyD88 signaling and lipid remodeling

Cell Reports(2025)10.1016/j.celrep.2025.116749Source: DataRank Database

Aromatic microbial metabolite hippuric acid enhances inflammatory responses in macrophages via TLR-MyD88 signaling and lipid remodeling is a research paper published in Cell Reports (2025). On theSindex it has a DataRank of 0. It has been cited 4 times.

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0DataRank · unranked

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Open Access4 citations

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Enrichment:Funding (7 grants)Impact (FWCI 2.32)OA: goldTopics (49)IDs (PubMed, PMC, OpenAlex)Annotations (1)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (15)

Sajad A. Bhat ORCID,Mohamed El Sayed ORCID,Sarah Kim Reiser ORCID,Siva Pushpa Gavara,Ying Ye ORCID

Live enrichment

PubMed:41477766 PMC:PMC12884656 OpenAlex:https://openalex.org/W7117648023

National Institute of Allergy and Infectious Diseases

Grant: K99 AI151198

Wistar Institute

Grant: S10 OD023586

Wistar Institute

Grant: P30 CA010815

Pancreatic Cancer Action Network

Grant: 22-20-SHIN

National Institutes of Health National Cancer Institute

Grant: R21 CA259240

National Institutes of Health National Cancer Institute

Grant: R37 CA280869

Margaret Q. Landenberger Research Foundation

FWCI

2.32

Citation Percentile

0.9%

Citation Trend

2026

goldLicense: cc-by-nc-nd

journalhttps://doi.org/10.1016/j.celrep.2025.116749

publisherhttps://doi.org/10.1016/j.celrep.2025.116749

publisherhttps://api.elsevier.com/content/article/PII:S2211124725015219?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S2211124725015219?httpAccept=text/plain

repositoryhttps://pubmed.ncbi.nlm.nih.gov/41477766

Fields of Study

Immune cells in cancerGut microbiota and healthImmune Response and InflammationMyeloid Differentiation Factor 88AnimalsMacrophagesHippuratesMiceSignal TransductionInflammationHumansMice, Inbred C57BLToll-Like ReceptorsLipid MetabolismEscherichia coli InfectionsImmunity, Innate

MeSH Terms

AnimalsEscherichia coli InfectionsHippuratesHumansImmunity, InnateInflammationMacrophagesMice, Inbred C57BLSignal TransductionLipid MetabolismToll-Like ReceptorsMiceMyeloid Differentiation Factor 88

Keywords

Hippuric acidMetaboliteInnate immune systemLipid metabolismMetabolismMicrobiomeImmune systemReceptorTranscriptomeMacrophagesSepsisBiomarkerCholesterol BiosynthesisMicrobial MetaboliteMacrophage PolarizationLipid RemodelingInflammation And InfectionCp: ImmunologyCp: MetabolismTlr-myd88 Signaling

Sustainable Development Goals

SDG 0: Good health and well-being

Aromatic microbial metabolite hippuric acid enhances inflammatory responses in macrophages via TLR-MyD88 signaling and lipid remodeling

FAIR Checklist

Authors (15)

Funding (7 grants)

Impact

Open Access

Topics

Annotations (Europe PMC)