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Inhibition of Resistance-Refractory P. falciparum Kinase PKG Delivers Prophylactic, Blood Stage, and Transmission-Blocking Antiplasmodial Activity

Cell chemical biology(2020)10.1016/j.chembiol.2020.04.001Source: DataRank Database

Inhibition of Resistance-Refractory P. falciparum Kinase PKG Delivers Prophylactic, Blood Stage, and Transmission-Blocking Antiplasmodial Activity is a research paper published in Cell chemical biology (2020). On theSindex it has a DataRank of 0. It has been cited 91 times.

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Open Access91 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

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Enrichment:Funding (15 grants)Impact (FWCI 9.71)OA: hybridTopics (85)IDs (PubMed, PMC, OpenAlex)Annotations (4)SDGs (2)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (31)

James M. Murithi ORCID,Charisse Flerida A. Pasaje ORCID,Sonja Ghidelli‐Disse ORCID,Louis Dwomoh ORCID,Megan J. Bird

Live enrichment

PubMed:32359426 PMC:PMC7369637 OpenAlex:https://openalex.org/W3023180438

Human Frontier Science Program

Grant: MMV030084

Human Frontier Science Program

Grant: MMV030734

Human Frontier Science Program

Grant: TCMDC-140369

Human Frontier Science Program

Grant: TCMDC-141019

National Institutes of Health

Grant: R01 AI090141

Medicines for Malaria Venture

Grant: 08/0015

National Institutes of Health

Grant: 5R01AI090141-08

Discovery of chemically validated malaria liver stage targets

University of Cape Town

London School of Hygiene and Tropical Medicine

National Research Foundation

Bill and Melinda Gates Foundation

GlaxoSmithKline España

Wellcome Trust

South African Medical Research Council

Wellcome Trust

FWCI

9.71

Citation Percentile

1.0%

Citation Trend

2020

2021

2022

2023

2024

2025

2026

hybridLicense: cc-by

journalhttp://www.cell.com/article/S245194562030115X/pdf

publisherhttp://www.cell.com/article/S245194562030115X/pdf

publisherhttps://api.elsevier.com/content/article/PII:S245194562030115X?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S245194562030115X?httpAccept=text/plain

journalhttps://doi.org/10.1016/j.chembiol.2020.04.001

Fields of Study

Malaria Research and ControlComputational Drug Discovery MethodsResearch on Leishmaniasis Studies0301 basic medicine03 medical and health sciences0303 health sciencesAnimalsAntimalarialsBinding SitesCyclic GMP-Dependent Protein KinasesDrug ResistanceFemaleHepatocytesHumansImidazolesLife Cycle StagesMetabolomicsMiceMice, Inbred BALB CMolecular Docking SimulationPlasmodium falciparumProteomicsProtozoan Proteins

MeSH Terms

AnimalsAntimalarialsBinding SitesDrug ResistanceFemaleHumansImidazolesLife Cycle StagesMice, Inbred BALB CPlasmodium falciparumProtozoan ProteinsCyclic GMP-Dependent Protein KinasesHepatocytesProteomicsMiceMetabolomicsMolecular Docking Simulation

Keywords

Plasmodium falciparumBiologyProtein kinase AKinaseCell biologyMalariaImmunologyResistanceTarget IdentificationPhosphoproteomicsConditional knockdownChemoproteomicsCgmp-dependent Protein Kinase (Pkg)Malaria Drug Discovery/dk/atira/pure/subjectarea/asjc/1300/1313Proteomics/dk/atira/pure/subjectarea/asjc/1300/1312Drug ResistanceProtozoan Proteins610name=Clinical Biochemistryname=PharmacologyArticleAntimalarialsMice615name=Molecular MedicineCyclic GMP-Dependent Protein KinasesAnimalsHumansMetabolomics/dk/atira/pure/subjectarea/asjc/1300/1303Life Cycle StagesMice, Inbred BALB CBinding Sites/dk/atira/pure/subjectarea/asjc/3000/3004Imidazolesname=Biochemistryname=Molecular BiologyMolecular Docking SimulationHepatocytesFemale/dk/atira/pure/subjectarea/asjc/3000/3002/dk/atira/pure/subjectarea/asjc/1300/1308name=Drug Discovery

Sustainable Development Goals

SDG 3: 3. Good healthSDG 0: Responsible consumption and production

Inhibition of Resistance-Refractory P. falciparum Kinase PKG Delivers Prophylactic, Blood Stage, and Transmission-Blocking Antiplasmodial Activity

FAIR Checklist

Authors (31)

Funding (15 grants)

Impact

Open Access

Topics

Annotations (Europe PMC)