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Hypomorph mutation-directed small-molecule protein-protein interaction inducers to restore mutant SMAD4-suppressed TGF-β signaling

Cell chemical biology(2020)10.1016/j.chembiol.2020.11.010Source: DataRank Database

Hypomorph mutation-directed small-molecule protein-protein interaction inducers to restore mutant SMAD4-suppressed TGF-β signaling is a research paper published in Cell chemical biology (2020). On theSindex it has a DataRank of 0. It has been cited 39 times.

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Open Access39 citations

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Enrichment:Funding (9 grants)OA: greenTopics (34)IDs (PubMed, PMC)Annotations (1)

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Open Access

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Reusable (0/3)

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Authors (9)

Xiulei Mo ORCID,Qiankun Niu ORCID,Alafate Wahafu ORCID,Xuan Yang ORCID,Min Qui

Live enrichment

PubMed:33326750 PMC:PMC10053325

National Institutes of Health

Grant: 5P30CA138292

National Cancer Institute

Grant: P50CA217691

Emory Alcohol and Lung Biology Center, Emory University School of Medicine

Grant: UL1-TR002378

Cancer Genomics Cancer Target Discovery and Development

Grant: U01CA217875

NCATS NIH HHS

Grant: UL1 TR002378

NCI NIH HHS

Grant: P30 CA138292

Emory School of Medicine

Winship Cancer Institute

National Cancer Institute's Office

greenLicense: http://www.elsevier.com/open-access/userlicense/1.0/

repositoryhttps://pmc.ncbi.nlm.nih.gov/articles/PMC10053325/pdf/nihms-1850914.pdf

publisherhttps://api.elsevier.com/content/article/PII:S2451945620304736?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S2451945620304736?httpAccept=text/plain

Fields of Study

Cell LineFemaleFluorescence Resonance Energy TransferGenes, Tumor SuppressorHumansIndolesMaleProtein BindingSignal TransductionSmad4 ProteinSmall Molecule LibrariesTransforming Growth Factor beta

MeSH Terms

Cell LineHumansIndolesTransforming Growth Factor betaFluorescence Resonance Energy TransferSignal TransductionProtein BindingGenes, Tumor SuppressorFemaleMaleSmad4 ProteinSmall Molecule Libraries

Keywords

Smad3Smad4TGF-beta signalingprotein-protein interaction (PPI)Tr-fretHigh-throughput Screening (Hts)Molecular GluePpi ActivatorPpi InducerHypomorph Mutation

Hypomorph mutation-directed small-molecule protein-protein interaction inducers to restore mutant SMAD4-suppressed TGF-β signaling

FAIR Checklist

Authors (9)

Funding (9 grants)

Open Access

Topics

Annotations (Europe PMC)