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CYP27A1-dependent anti-melanoma activity of limonoid natural products targets mitochondrial metabolism

Cell chemical biology(2021)10.1016/j.chembiol.2021.03.004Source: DataRank Database

CYP27A1-dependent anti-melanoma activity of limonoid natural products targets mitochondrial metabolism is a research paper published in Cell chemical biology (2021). On theSindex it has a DataRank of 0. It has been cited 27 times.

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Open Access27 citations

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CCDC 2061432: Experimental Crystal Structure Determination · Cambridge Crystallographic Data Centre

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Enrichment:Funding (7 grants)Impact (FWCI 1.26)OA: greenTopics (56)Linked Datasets (1)DataCite Reuse (1)IDs (PubMed, PMC, OpenAlex)Annotations (2)SDGs (1)

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Context only (not used in score)

Findable (2/2)

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Accessible (1/2)

Open Access

Interoperable (2/2)

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Reusable (0/3)

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Authors (28)

Qiong Shen ORCID,Lydia H. Zhang ORCID,Mikiko Okumura,Akinori Kawakami ORCID,Jessi Ambrose

Live enrichment

PubMed:33794192 PMC:PMC8481390 OpenAlex:https://openalex.org/W3145299904

National Institutes of Health

Grant: 5P01 CA163222-07

National Institutes of Health

Grant: 5R01 AR043369-24

NIAMS NIH HHS

Grant: R01 AR043369

NCI NIH HHS

Grant: P01 CA163222

Novartis Institutes for BioMedical Research

Massachusetts General Hospital

Dr. Miriam and Sheldon G. Adelson Medical Research Foundation

FWCI

1.26

Citation Percentile

0.8%

Citation Trend

2021

2022

2023

2024

2025

2026

greenLicense: http://www.elsevier.com/open-access/userlicense/1.0/

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/8481390

publisherhttps://api.elsevier.com/content/article/PII:S2451945621001434?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S2451945621001434?httpAccept=text/plain

journalhttps://doi.org/10.1016/j.chembiol.2021.03.004

Fields of Study

Phytochemical compounds biological activitiesMicrobial Natural Products and BiosynthesisMelanoma and MAPK PathwaysAntineoplastic AgentsBiological ProductsCell Line, TumorCell ProliferationCholestanetriol 26-MonooxygenaseHumansLimoninsMelanomaMicrophthalmia-Associated Transcription FactorMitochondriaOxidative PhosphorylationPromoter Regions, GeneticProtein BindingProto-Oncogene Proteins B-rafRNA InterferenceRNA, Small Interfering

MeSH Terms

Antineoplastic AgentsBiological ProductsHumansMelanomaMitochondriaOxidative PhosphorylationPromoter Regions, GeneticProtein BindingRNA InterferenceRNA, Small InterferingLimoninsCell Line, TumorProto-Oncogene Proteins B-rafCell ProliferationMicrophthalmia-Associated Transcription FactorCholestanetriol 26-Monooxygenase

Keywords

Microphthalmia-associated transcription factorBiologyMitochondrionMitochondrial biogenesisNeuroblastoma RAS viral oncogene homologCell biologyTranscription factorBiochemistryCancer researchGeneMutationMelanomaOxidative phosphorylationNatural productsProdrugmitochondrial complex IOncologyBrafMitfCancer MetabolismCyp27a1

Sustainable Development Goals

SDG 0: Good health and well-being

CCDC 2061432: Experimental Crystal Structure Determination

10.5517/ccdc.csd.cc2762tcCambridge Crystallographic Data Centre

CYP27A1-dependent anti-melanoma activity of limonoid natural products targets mitochondrial metabolism

FAIR Checklist

Authors (28)

Funding (7 grants)

Impact

Open Access

Topics

Linked Datasets (1)

Annotations (Europe PMC)