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Chemically modified guide RNAs enhance CRISPR-Cas13 knockdown in human cells

Cell chemical biology(2021)10.1016/j.chembiol.2021.07.011Source: DataRank Database

Chemically modified guide RNAs enhance CRISPR-Cas13 knockdown in human cells is a research paper published in Cell chemical biology (2021). On theSindex it has a DataRank of 0. It has been cited 63 times.

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0DataRank · unranked

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Open Access63 citations

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Enrichment:Funding (13 grants)Impact (FWCI 4.00)OA: greenTopics (43)Linked Datasets (16)DataCite Reuse (16)IDs (PubMed, PMC, OpenAlex)Annotations (1)

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Context only (not used in score)

Findable (2/2)

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Accessible (1/2)

Open Access

Interoperable (2/2)

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Reusable (0/3)

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Authors (9)

Hans‐Hermann Wessels ORCID,Mateusz Legut ORCID,Anastasia P. Kadina,Megumu Mabuchi,John Walker ORCID

Live enrichment

PubMed:34343484 PMC:PMC8792099 OpenAlex:https://openalex.org/W3190407283

National Human Genome Research Institute

Grant: DP2HG010099

National Cancer Institute

Grant: R01CA218668

National Institute of General Medical Sciences

Grant: R01GM138635

Defense Advanced Research Projects Agency

Grant: D18AP00053

National Institutes of Health

Grant: 5R01EY000053-19

NEURAL MECHANISMS OF VISION

National Institutes of Health

Grant: 1R01GM138635-01

Organizational principles and functional role of 3D enhancer hubs in cell fate decisions

National Institutes of Health

Grant: 3R01CA218668-04S2

Computational Methods for Identifying Non-coding Cancer Drivers

National Institutes of Health

Grant: 3DP2HG010099-01S2

In situ functional genomics to understand transcriptional regulation

Cancer Research Institute

New York University

National Institutes of Health

Brain and Behavior Research Foundation

New York Genome Center

FWCI

4.00

Citation Percentile

1.0%

Citation Trend

2022

2023

2024

2025

2026

greenLicense: Elsevier Non-Commercial

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/8792099

publisherhttps://api.elsevier.com/content/article/PII:S2451945621003512?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S2451945621003512?httpAccept=text/plain

journalhttps://doi.org/10.1016/j.chembiol.2021.07.011

Fields of Study

CRISPR and Genetic EngineeringRNA Interference and Gene DeliveryAdvanced biosensing and bioanalysis techniques0301 basic medicine0303 health sciences03 medical and health sciencesCRISPR-Associated ProteinsCRISPR-Cas SystemsCells, CulturedGene EditingHumansRNA, Guide, CRISPR-Cas Systems

MeSH Terms

Gene EditingRNA, Guide, CRISPR-Cas SystemsCells, CulturedHumansRNA, Guide, KinetoplastidaCRISPR-Cas SystemsCRISPR-Associated Proteins

Keywords

Trans-activating crRNACRISPRGene knockdownRNARibonucleoproteinRNA interferenceComputational biologyHEK 293 cellsBiologyGeneGenome editingCell biologyChemistryGeneticsChemical ModificationsTranscriptome RegulationCas13Crispr Type-viGene EditingCRISPR-Associated ProteinsHumansCRISPR-Cas SystemsRNA, Guide, CRISPR-Cas SystemsCells, Cultured

Additional file 1 of CRISPR-dCas13-tracing reveals transcriptional memory and limited mRNA export in developing zebrafish embryos

10.6084/m9.figshare.22605964.v1figshare

Additional file 1 of CRISPR-dCas13-tracing reveals transcriptional memory and limited mRNA export in developing zebrafish embryos

10.6084/m9.figshare.22605964figshare

Additional file 7 of CRISPR-dCas13-tracing reveals transcriptional memory and limited mRNA export in developing zebrafish embryos

10.6084/m9.figshare.22605985.v1figshare

Additional file 7 of CRISPR-dCas13-tracing reveals transcriptional memory and limited mRNA export in developing zebrafish embryos

10.6084/m9.figshare.22605985figshare

Additional file 8 of CRISPR-dCas13-tracing reveals transcriptional memory and limited mRNA export in developing zebrafish embryos

10.6084/m9.figshare.22605988.v1figshare

Additional file 8 of CRISPR-dCas13-tracing reveals transcriptional memory and limited mRNA export in developing zebrafish embryos

10.6084/m9.figshare.22605988figshare

Additional file 6 of CRISPR-dCas13-tracing reveals transcriptional memory and limited mRNA export in developing zebrafish embryos

10.6084/m9.figshare.22605979figshare

Additional file 5 of CRISPR-dCas13-tracing reveals transcriptional memory and limited mRNA export in developing zebrafish embryos

10.6084/m9.figshare.22605976.v1figshare

Additional file 4 of CRISPR-dCas13-tracing reveals transcriptional memory and limited mRNA export in developing zebrafish embryos

10.6084/m9.figshare.22605973figshare

Additional file 2 of CRISPR-dCas13-tracing reveals transcriptional memory and limited mRNA export in developing zebrafish embryos

10.6084/m9.figshare.22605967figshare

Additional file 2 of CRISPR-dCas13-tracing reveals transcriptional memory and limited mRNA export in developing zebrafish embryos

10.6084/m9.figshare.22605967.v1figshare

Additional file 5 of CRISPR-dCas13-tracing reveals transcriptional memory and limited mRNA export in developing zebrafish embryos

10.6084/m9.figshare.22605976figshare

Additional file 6 of CRISPR-dCas13-tracing reveals transcriptional memory and limited mRNA export in developing zebrafish embryos

10.6084/m9.figshare.22605979.v1figshare

Additional file 3 of CRISPR-dCas13-tracing reveals transcriptional memory and limited mRNA export in developing zebrafish embryos

10.6084/m9.figshare.22605970.v1figshare

Additional file 4 of CRISPR-dCas13-tracing reveals transcriptional memory and limited mRNA export in developing zebrafish embryos

10.6084/m9.figshare.22605973.v1figshare

Additional file 3 of CRISPR-dCas13-tracing reveals transcriptional memory and limited mRNA export in developing zebrafish embryos

10.6084/m9.figshare.22605970figshare

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Chemically modified guide RNAs enhance CRISPR-Cas13 knockdown in human cells

FAIR Checklist

Authors (9)

Funding (13 grants)

Impact

Open Access

Topics

Linked Datasets (16)

Annotations (Europe PMC)

Related Papers (10)