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Generation of an anticoagulant aptamer that targets factor V/Va and disrupts the FVa-membrane interaction in normal and COVID-19 patient samples

Cell chemical biology(2022)10.1016/j.chembiol.2022.01.009Source: DataRank Database

Generation of an anticoagulant aptamer that targets factor V/Va and disrupts the FVa-membrane interaction in normal and COVID-19 patient samples is a research paper published in Cell chemical biology (2022). On theSindex it has a DataRank of 0. It has been cited 12 times.

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Open Access12 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (4 grants)Impact (FWCI 1.48)OA: bronzeTopics (92)IDs (PubMed, PMC, OpenAlex)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (7)

Haixiang Yu ORCID,Lyra B. Olson ORCID,Ibtehaj A. Naqvi ORCID,Shekhar Kumar ORCID,Sriram Krishnaswamy ORCID

Live enrichment

PubMed:35114109 PMC:PMC8808741 OpenAlex:https://openalex.org/W4210497525

National Institutes of Health

Grant: P01-HL139420

NIGMS NIH HHS

Grant: T32 GM145449

NHLBI NIH HHS

Grant: P01 HL139420

National Institutes of Health

Grant: 5P01HL139420-03

Hemostasis and Thrombosis: Chemistry, Biology and Physiology

FWCI

1.48

Citation Percentile

0.8%

Citation Trend

2023

2024

2025

2026

bronzeLicense: Elsevier Non-Commercial

journalhttp://www.cell.com/article/S2451945622000514/pdf

BRONZEhttp://www.cell.com/article/S2451945622000514/pdf

publisherhttp://www.cell.com/article/S2451945622000514/pdf

publisherhttps://api.elsevier.com/content/article/PII:S2451945622000514?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S2451945622000514?httpAccept=text/plain

Fields of Study

Blood Coagulation and Thrombosis MechanismsAdvanced biosensing and bioanalysis techniquesExtracellular vesicles in diseaseMedicineChemistry0301 basic medicine03 medical and health sciencesAmino Acid SequenceAnticoagulantsAptamers, NucleotideBase PairingBinding SitesBlood CoagulationCOVID-19Cell MembraneFactor VFactor VaHeparin, Low-Molecular-WeightHumansImmune SeraModels, MolecularNucleic Acid ConformationProtaminesProtein BindingProtein Conformation, alpha-HelicalProtein Conformation, beta-StrandProtein Interaction Domains and MotifsSARS-CoV-2SELEX Aptamer TechniqueSubstrate SpecificityCOVID-19 Drug Treatment

MeSH Terms

Protein Conformation, alpha-HelicalProtein Conformation, beta-StrandCOVID-19SARS-CoV-2COVID-19 Drug TreatmentAmino Acid SequenceAnticoagulantsBinding SitesBlood CoagulationCell MembraneFactor VHeparin, Low-Molecular-WeightHumansImmune SeraModels, MolecularNucleic Acid ConformationProtaminesProtein BindingSubstrate SpecificityFactor VaBase PairingSELEX Aptamer TechniqueAptamers, NucleotideProtein Interaction Domains and Motifs

Keywords

AptamerChemistryAnticoagulantCoagulationHemostasisProtein CPharmacologyBiochemistryMolecular biologyMedicineBiologyInternal medicineThrombosisProtein InhibitorProtein-membrane InteractionFactor V/vaCovid-19Models, MolecularProtein Conformation, alpha-HelicalBinding SitesImmune SeraCell MembraneAnticoagulantsFactor VAptamers, NucleotideHeparin, Low-Molecular-WeightArticleFactor VaHumansNucleic Acid ConformationProtein Conformation, beta-StrandProtein Interaction Domains and MotifsAmino Acid SequenceProtaminesBase PairingBlood CoagulationProtein Binding

Sustainable Development Goals

SDG 3: 3. Good health