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An engineered cereblon optimized for high-throughput screening and molecular glue discovery

Cell chemical biology(2024)10.1016/j.chembiol.2024.11.002Source: DataRank Database

An engineered cereblon optimized for high-throughput screening and molecular glue discovery is a research paper published in Cell chemical biology (2024). On theSindex it has a DataRank of 0. It has been cited 22 times.

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Open Access22 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (11 grants)OA: hybridTopics (31)IDs (PubMed)

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Open Access

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Reusable (0/3)

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Authors (26)

Jonathan Eisert ORCID,Rubina Kazi,Jan Gerhartz ORCID,Dominika Ewa Pieńkowska,Ina Dressel

Live enrichment

PubMed:39610248

Deutsche Forschungsgemeinschaft

Grant: 259130777

Deutsche Forschungsgemeinschaft

Grant: SFB1177

National Institutes of Health

Grant: CA214608

National Institutes of Health

Grant: CA218278

Federal Ministry of Education and Research Bonn Office

Grant: EXC2151\u2013390873048

Federal Ministry of Education and Research Bonn Office

Grant: 03ZU1109FA

National Institutes of Health

Grant: 5R01CA218278-03

Degrading therapeutically important kinases using small molecules

National Institutes of Health

Grant: 5R01CA214608-05

The molecular basis of IMiD induced neo-substrate recruitment to the CRL4CRBN ubiquitin E3 ligase.

Fundação para a Ciência e a Tecnologia, I.P.

Grant: PTDC/CCI-INF/6762/2020

MS3: New foundations for micro-services and serverless systems

Deutsche Forschungsgemeinschaft

Grant: unidentified

unidentified

Fundação para a Ciência e a Tecnologia

hybridLicense: cc-by

publisherhttps://doi.org/10.1016/j.chembiol.2024.11.002

publisherhttps://api.elsevier.com/content/article/PII:S2451945624004604?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S2451945624004604?httpAccept=text/plain

https://pubmed.ncbi.nlm.nih.gov/39610248

https://hdl.handle.net/21.11116/0000-0010-4187-C

Fields of Study

HumansHigh-Throughput Screening AssaysUbiquitin-Protein LigasesAdaptor Proteins, Signal TransducingProtein EngineeringLigandsProtein BindingImidazoles

MeSH Terms

HumansImidazolesUbiquitin-Protein LigasesAdaptor Proteins, Signal TransducingLigandsProtein EngineeringProtein BindingHigh-Throughput Screening Assays

Keywords

UbiquitinCereblonImidsTargeted Protein DegradationProtacsMolecular GluesDegradersUbiquitin-Protein LigasesImidazolesHumansProtein EngineeringLigandsHigh-Throughput Screening AssaysAdaptor Proteins, Signal TransducingProtein Binding