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Genome-Wide CRISPR Screen Identifies Semaphorin 6A and 6B as Receptors for Paeniclostridium sordellii Toxin TcsL

Cell Host & Microbe(2020)10.1016/j.chom.2020.03.007Source: DataRank Database

Genome-Wide CRISPR Screen Identifies Semaphorin 6A and 6B as Receptors for Paeniclostridium sordellii Toxin TcsL is a research paper published in Cell Host & Microbe (2020). On theSindex it has a DataRank of 0. It has been cited 40 times.

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Enrichment:Funding (23 grants)Impact (FWCI 0.51)OA: bronzeTopics (74)IDs (PubMed, PMC, OpenAlex)Annotations (1)SDGs (2)

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Open Access

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Reusable (0/3)

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Authors (9)

Yang Liu ORCID,Hao Wu ORCID,Hao Liu ORCID,Ji Zeng ORCID,Mei Yuk Choi

Live enrichment

PubMed:32302524 PMC:PMC7228847 OpenAlex:https://openalex.org/W3017086605

National Institutes of Health

Grant: R01AI132387

National Institutes of Health

Grant: R01AI139087

National Institutes of Health

Grant: R01HL093242

National Institutes of Health

Grant: R01HL130845

National Institutes of Health

Grant: R01NS080833

National Institutes of Health

Grant: R21NS106159

Intellectual and Developmental Disabilities Research Center

Grant: P30HD18655

Intelligence Advanced Research Projects Activity

Grant: W911NF-17-2-0089

NHLBI NIH HHS

Grant: R01 HL146134

NIDDK NIH HHS

Grant: P30 DK034854

NCI NIH HHS

Grant: R21 CA235533

NICHD NIH HHS

Grant: P30 HD018655

NHLBI NIH HHS

Grant: R01 HL118676

NHLBI NIH HHS

Grant: R01 HL137229

National Institutes of Health

Grant: 5R01HL130845-03

Mechanisms regulating VEGF receptors in diabetic angiogenesis

National Institutes of Health

Grant: 5R01HL093242-12

Epsin in Angiogenesis and Vascular Remodeling

National Institutes of Health

Grant: 5R21NS106159-02

Molecular mechanism for retrograde transport of tetanus neurotoxin

National Institutes of Health

Grant: 3P30HD018655-28S1

Mental Retardation and Developmental Disabilities Research Centers 2006

National Institutes of Health

Grant: 5R01NS080833-10

Biology and Engineering of Botulinum Neurotoxins.

National Institutes of Health

Grant: 5P30DK034854-32

Integrated Epithelial and Mucosal Biology

National Institutes of Health

Grant: 5R01AI139087-04

Structure and Function of C. Difficile Toxins

National Institutes of Health

Grant: 5R01AI132387-02

Molecular basis of action and pathogenesis of Clostridium difficile toxin B

Burroughs Wellcome Fund

FWCI

0.51

Citation Percentile

0.8%

Citation Trend

2020

2021

2022

2023

2024

2025

2026

bronzeLicense: Elsevier Non-Commercial

journalhttp://www.cell.com/article/S1931312820301712/pdf

publisherhttp://www.cell.com/article/S1931312820301712/pdf

publisherhttps://api.elsevier.com/content/article/PII:S1931312820301712?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S1931312820301712?httpAccept=text/plain

journalhttps://doi.org/10.1016/j.chom.2020.03.007

Fields of Study

Clostridium difficile and Clostridium perfringens researchToxin Mechanisms and ImmunotoxinsPharmacological Effects of Natural Compounds0301 basic medicine0303 health sciences03 medical and health sciences

MeSH Terms

A549 CellsAnimalsBacterial ProteinsBacterial ToxinsBinding SitesFemaleHeLa CellsHumansLung NeoplasmsMaleProtein BindingVirulence FactorsSemaphorinsEndothelial CellsCell Line, TumorParaclostridium sordelliiClostridium sordelliiMiceGene Knockout TechniquesClustered Regularly Interspaced Short Palindromic RepeatsCRISPR-Cas SystemsHela Cells

Keywords

BiologyReceptorExotoxinSemaphorinFrizzledClostridium difficile toxin BToxinCell cultureVirulence factorVirulenceMolecular biologyClostridium difficile toxin ACell biologyMicrobiologyGeneticsWnt signaling pathwayGeneSignal transductionClostridium difficileBacterial ToxinClostridium SordelliiTcslLarge Clostridial ToxinCrispr ScreenPaeniclostridium SordelliiSemaphorin 6,Clostridium DifficileMaleBinding SitesLung NeoplasmsVirulence FactorsBacterial ToxinsEndothelial CellsSemaphorinsParaclostridium sordelliiGene Knockout TechniquesMiceBacterial ProteinsA549 CellsCell Line, TumorAnimalsHumansClustered Regularly Interspaced Short Palindromic RepeatsFemaleCRISPR-Cas SystemsHeLa CellsProtein Binding

Sustainable Development Goals

SDG 3: 3. Good healthSDG 0: Good health and well-being

Genome-Wide CRISPR Screen Identifies Semaphorin 6A and 6B as Receptors for Paeniclostridium sordellii Toxin TcsL

FAIR Checklist

Authors (9)

Funding (23 grants)

Impact

Open Access

Topics

Annotations (Europe PMC)