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Beta Cell Dedifferentiation Induced by IRE1α Deletion Prevents Type 1 Diabetes

Cell Metabolism(2020)10.1016/j.cmet.2020.03.002Source: DataRank Database

Beta Cell Dedifferentiation Induced by IRE1α Deletion Prevents Type 1 Diabetes is a research paper published in Cell Metabolism (2020). On theSindex it has a DataRank of 0. It has been cited 157 times.

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Enrichment:Funding (14 grants)OA: bronzeTopics (15)Linked Datasets (10)DataCite Reuse (10)IDs (PubMed)

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Authors (13)

Yong-Syu Lee,Quincy Eckert Harenda,Stefan Pietrzak,Hülya Zeynep Oktay ORCID,Sierra Schreiber

Live enrichment

PubMed:19767382

National Institutes of Health

Grant: DK107541

National Institutes of Health

Grant: DK118786

National Institutes of Health

Grant: T32 GM007215

National Institutes of Health

Grant: T32 NHGRI 5T32HG002760

National Institutes of Health

Grant: DK121747

National Institutes of Health

Grant: R01GM113033

National Institutes of Health

Grant: 1F31DK118786-01A1

The role of IL-27 signaling in the accumulation and sustained effector function of autoreactive CD8 T cells in type 1 diabetes

National Institutes of Health

Grant: 1R01GM113033-01A1

Collaboration of chromatin remodeling and signaling pathways in pluripotency

National Institutes of Health

Grant: 1R01DK121747-01

Shaping diabetogenic T cells by IL-27 in type 1 diabetes

National Institutes of Health

Grant: 5P30CA014520-18

CANCER CENTER SUPPORT

National Institutes of Health

Grant: 1R01DK107541-01A1

Mechanistic and Therapeutic Role of the CD137-CD137L Axis in Type 1 Diabetes

National Institutes of Health

Grant: 2T32HG002760-21

Institutional Training in the Genomic Sciences

National Institutes of Health

Grant: 5K01DK102488-03

Beta cell endoplasmic reticulum stress and its crosstalk with immune system in ty

National Institutes of Health

Grant: 2T32GM007215-36

Graduate Training in Molecular Biosciences

bronzeLicense: Elsevier Non-Commercial

publisherhttp://www.cell.com/article/S1550413120301170/pdf

publisherhttps://api.elsevier.com/content/article/PII:S1550413120301170?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S1550413120301170?httpAccept=text/plain

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/7346095

https://doi.org/10.1016/j.cmet.2020.03.002

Fields of Study

03 medical and health sciences0302 clinical medicine

Keywords

Mice, KnockoutCD8-Positive T-LymphocytesCell DedifferentiationProtein Serine-Threonine KinasesMiceDiabetes Mellitus, Type 1Mice, Inbred NODHyperglycemiaInsulin-Secreting CellsEndoribonucleasesUnfolded Protein ResponseAnimalsGene Deletion

Additional file 2 of Deficiency of Trex1 leads to spontaneous development of type 1 diabetes

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Additional file 2 of Deficiency of Trex1 leads to spontaneous development of type 1 diabetes

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Additional file 3 of Deficiency of Trex1 leads to spontaneous development of type 1 diabetes

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Additional file 3 of Deficiency of Trex1 leads to spontaneous development of type 1 diabetes

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Additional file 4 of Deficiency of Trex1 leads to spontaneous development of type 1 diabetes

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Additional file 4 of Deficiency of Trex1 leads to spontaneous development of type 1 diabetes

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Additional file 5 of Deficiency of Trex1 leads to spontaneous development of type 1 diabetes

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Additional file 5 of Deficiency of Trex1 leads to spontaneous development of type 1 diabetes

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Additional file 1 of Deficiency of Trex1 leads to spontaneous development of type 1 diabetes

10.6084/m9.figshare.24934234figshare

Additional file 1 of Deficiency of Trex1 leads to spontaneous development of type 1 diabetes

10.6084/m9.figshare.24934234.v1figshare