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CD24-Siglec axis is an innate immune checkpoint against metaflammation and metabolic disorder

Cell Metabolism(2022)10.1016/j.cmet.2022.07.005Source: DataRank Database

CD24-Siglec axis is an innate immune checkpoint against metaflammation and metabolic disorder is a research paper published in Cell Metabolism (2022). On theSindex it has a DataRank of 1.8. It has been cited 68 times, with 66 citing works in its 1-hop citation network.

N/A

1.8DataRank · unranked

Scored on demand from live citation data

Deposits data Open Access68 citations · 66 citing works in its network

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Linked data & code

geo gen nct rrid

Data availability

Repositories this paper deposited data in (declared in PubMed).

ClinicalTrials.govNCT02650895

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (12 grants)Impact (FWCI 6.57)OA: hybridTopics (43)IDs (PubMed, PMC, OpenAlex)Annotations (4)SDGs (2)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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DataRank Breakdown

Base Score 36%Citation Network 64%

Base Score Contribution

0.635

From this paper's citation signal

Citation Network Contribution

1.2

From 51 citing papers with measurable signal

Learn more about DataRank methodology →

Top 5 citers driving the network score

Ranked by each citer's contribution to N(p) — log1p(C_q) divided by its reference count — out of 66 citers.

Integrated genetic analysis of diabetic complications: Bioinformatics insights into foot ulcers, neuropathy and peripheral artery disease
International Wound Journal202412 citations23 referencesContributes 0.112
Inhaled Exosomes Genetically Manipulated to Overexpress CD24 (EXO-CD24) as a Compassionate Use in Severe ARDS Patients
Biomedicines202318 citations33 referencesContributes 0.089
Inhaled CD24-Enriched Exosomes (EXO-CD24) as a Novel Immune Modulator in Respiratory Disease
International Journal of Molecular Sciences202315 citations39 referencesContributes 0.071
CD24 negativity reprograms mitochondrial metabolism to PPARα and NF-κB-driven fatty acid β-oxidation in triple-negative breast cancer
Cancer Letters202436 citations70 referencesContributes 0.052
Bispecific BCMA/CD24 CAR-T cells control multiple myeloma growth
Nature Communications202444 citations74 referencesContributes 0.051

Authors (16)

Mingyue Liu ORCID,Jifeng Zhang ORCID,Nicholas K. Brown ORCID,Peng Zhang ORCID,Yan Zhang ORCID

Live enrichment

PubMed:35921817 PMC:PMC9393047 OpenAlex:https://openalex.org/W4289525498

National Institutes of Health

Grant: NS080821

National Institutes of Health

Grant: AI64350

National Institutes of Health

Grant: CA227671

National Institutes of Health

Grant: OncoC4

NIAID NIH HHS

Grant: R01 AI064350

NCI NIH HHS

Grant: R01 CA227671

NIAID NIH HHS

Grant: R01 AI137255

NINDS NIH HHS

Grant: R01 NS080821

National Institutes of Health

Grant: 5R01AI064350-05

Checkpoints of Host Response to Cellular Injuries

National Institutes of Health

Grant: 5R01CA227671-02

A Mouse Model to Assess Long Term Immunotherapy-related Adverse Effects in Children

National Institutes of Health

Grant: 5R01NS080821-02

CD24 Targeting for Multiple Sclerosis: a First-In-Human Phase I Study

Medpace

FWCI

6.57

Citation Percentile

1.0%

Citation Trend

2022

2023

2024

2025

2026

hybridLicense: cc-by

journalhttp://www.cell.com/article/S1550413122003047/pdf

publisherhttp://www.cell.com/article/S1550413122003047/pdf

publisherhttps://api.elsevier.com/content/article/PII:S1550413122003047?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S1550413122003047?httpAccept=text/plain

journalhttps://doi.org/10.1016/j.cmet.2022.07.005

Fields of Study

Advanced Glycation End Products researchAtherosclerosis and Cardiovascular DiseasesBiomarkers in Disease Mechanisms0301 basic medicine0303 health sciences03 medical and health sciences

MeSH Terms

Clinical Studies as TopicAnimalsHumansInflammationMetabolic DiseasesObesityPhagocytosisMiceCD24 AntigenSialic Acid Binding Immunoglobulin-like Lectins

Keywords

Innate immune systemSIGLECImmune checkpointBiologyImmunologyImmune systemCell biologyImmunotherapyObesityInsulin resistancemetabolic syndromeSialylationNASHSiglecsCd24MetaflammationSiglec-eSialic Acid-binding Immunoglobulin-like LectinsInflammationSialic Acid Binding Immunoglobulin-like LectinsClinical Studies as TopicCD24 AntigenMiceMetabolic DiseasesPhagocytosisAnimalsHumans

Sustainable Development Goals

SDG 3: 3. Good healthSDG 0: Good health and well-being