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DGAT2 inhibition blocks SREBP-1 cleavage and improves hepatic steatosis by increasing phosphatidylethanolamine in the ER

Cell Metabolism(2024)10.1016/j.cmet.2024.01.011Source: DataRank Database

DGAT2 inhibition blocks SREBP-1 cleavage and improves hepatic steatosis by increasing phosphatidylethanolamine in the ER is a research paper published in Cell Metabolism (2024). On theSindex it has a DataRank of 0. It has been cited 96 times.

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Open Access96 citations

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Enrichment:Funding (16 grants)Impact (FWCI 19.89)OA: hybridTopics (58)IDs (PubMed, PMC, OpenAlex)Annotations (1)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (9)

Mingfeng Xia ORCID,Gonçalo Vale ORCID,Simeng Wang ORCID,Chai-Wan Kim ORCID,Shili Li ORCID

Live enrichment

PubMed:38340721 PMC:PMC10939742 OpenAlex:https://openalex.org/W4391692569

Leducq Foundation

Grant: 19CVD04

Welch Foundation

Grant: I-1793

Science and Technology Commission of Shanghai Municipality

Grant: 23ZR1411000

NIH

Grant: P30DK127984

NIH

Grant: UL1TR003163

NIH

Grant: P01HL-160487

NIH

Grant: AI-158357

NHLBI NIH HHS

Grant: P01 HL160487

NIDDK NIH HHS

Grant: T32 DK007745

NIAID NIH HHS

Grant: R01 AI158357

National Institutes of Health

Grant: 5UL1TR003163-05

UT Southwestern Center for Translational Medicine

National Institutes of Health

Grant: 1P01HL160487-01

New Approaches to Reduce Residual Cardiovascular Risk

National Institutes of Health

Grant: 5R01AI158357-03

Oxysterol Regulation of Microbial Pathogenesis

National Institutes of Health

Grant: 1P30DK127984-01A1

UT Southwestern NORC

Pfizer

Merck

FWCI

19.89

Citation Percentile

1.0%

Citation Trend

2024

2025

2026

hybridLicense: cc-by-nc

journalhttps://doi.org/10.1016/j.cmet.2024.01.011

publisherhttps://doi.org/10.1016/j.cmet.2024.01.011

publisherhttps://api.elsevier.com/content/article/PII:S1550413124000111?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S1550413124000111?httpAccept=text/plain

repositoryhttps://pubmed.ncbi.nlm.nih.gov/38340721

Fields of Study

Lipid metabolism and biosynthesisLiver Disease Diagnosis and TreatmentDiet, Metabolism, and Disease0301 basic medicine03 medical and health sciencesAnimalsMiceDiacylglycerol O-AcyltransferaseEndoplasmic ReticulumLiverNon-alcoholic Fatty Liver DiseasePhosphatidylethanolaminesSterol Regulatory Element Binding Protein 1Triglycerides

MeSH Terms

AnimalsEndoplasmic ReticulumLiverPhosphatidylethanolaminesTriglyceridesDiacylglycerol O-AcyltransferaseMiceSterol Regulatory Element Binding Protein 1Non-alcoholic Fatty Liver Disease

Keywords

LipogenesisSteatosisSterol regulatory element-binding proteinEndoplasmic reticulumDiacylglycerol kinaseCleavage (geology)ChemistryTriglycerideEndocrinologyInternal medicineFatty liverPhosphatidylethanolamineBiochemistryPhospholipidBiologyCholesterolLipid metabolismSterolPhosphatidylcholineEnzymeMedicineSREBPsPEhepatic steatosisDgat2Diacylglycerol Acyltransferase 2MiceLiverNon-alcoholic Fatty Liver DiseasePhosphatidylethanolaminesAnimalsDiacylglycerol O-AcyltransferaseSterol Regulatory Element Binding Protein 1ArticleTriglycerides

Sustainable Development Goals

SDG 0: Good health and well-being

DGAT2 inhibition blocks SREBP-1 cleavage and improves hepatic steatosis by increasing phosphatidylethanolamine in the ER

FAIR Checklist

Authors (9)

Funding (16 grants)

Impact

Open Access

Topics

Annotations (Europe PMC)