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Pyruvate kinase M2 activation reprograms mitochondria in CD8 T cells, enhancing effector functions and efficacy of anti-PD1 therapy

Cell Metabolism(2025)10.1016/j.cmet.2025.03.003Source: DataRank Database

Pyruvate kinase M2 activation reprograms mitochondria in CD8 T cells, enhancing effector functions and efficacy of anti-PD1 therapy is a research paper published in Cell Metabolism (2025). On theSindex it has a DataRank of 0. It has been cited 35 times.

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0DataRank · unranked

Scored on demand from live citation data

Open Access35 citations

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datarank_citation_only_1hop_v6· scope data_onlyMethodology

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Enrichment:Funding (10 grants)Impact (FWCI 14.57)OA: greenTopics (34)IDs (PubMed, PMC, OpenAlex)Annotations (2)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (11)

Jignesh Soni,Jin Lu ORCID,Anil Kumar Yadav ORCID,Shivani Bansal ORCID,Tian Mi

Live enrichment

PubMed:40199327 PMC:PMC12137016 OpenAlex:https://openalex.org/W4409266623

American Cancer Society

Grant: 129819-IRG-21-049-61-IRG134

The 5th District Eagles Cancer Telethon

Grant: 23-01

Cancer Research Institute

Grant: CRI4831

NIH National Institute of General Medical Sciences

Grant: P30-CA051008

Basic Research Laboratory

Grant: R01CA237311

NCI NIH HHS

Grant: P30 CA051008

NCI NIH HHS

Grant: R01 CA276775

National Institutes of Health

National Cancer Institute

Mayo Clinic

FWCI

14.57

Citation Percentile

1.0%

Citation Trend

2025

2026

greenLicense: http://www.elsevier.com/open-access/userlicense/1.0/

repositoryhttps://pmc.ncbi.nlm.nih.gov/articles/PMC12137016/pdf/nihms-2064886.pdf

publisherhttps://api.elsevier.com/content/article/PII:S1550413125001068?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S1550413125001068?httpAccept=text/plain

repositoryhttps://pmc.ncbi.nlm.nih.gov/articles/PMC12137016/

Fields of Study

Immune Cell Function and InteractionImmune cells in cancerPhagocytosis and Immune Regulation

MeSH Terms

Immune Checkpoint InhibitorsAnimalsFemaleHumansMice, Inbred C57BLMitochondriaPyruvate KinaseCD8-Positive T-LymphocytesCell Line, TumorMiceProgrammed Cell Death 1 Receptor

Keywords

EffectorMitochondrionCell biologyCD8GlycolysisKinaseBiologyCancer researchChemistryMetabolismBiochemistryImmunologyImmune systemMitochondriaMelanomaImmunotherapyAdoptive Cell TherapyCd8 T CellsPkm2Pd1 Blockade

Sustainable Development Goals

SDG 0: Zero hunger