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Jagged-1 is induced by mTOR inhibitors in renal cancer cells through an Akt/ALK5/Smad4-dependent mechanism

Current Research in Pharmacology and Drug Discovery(2022)10.1016/j.crphar.2022.100117Source: DataRank Database

Jagged-1 is induced by mTOR inhibitors in renal cancer cells through an Akt/ALK5/Smad4-dependent mechanism is a research paper published in Current Research in Pharmacology and Drug Discovery (2022). On theSindex it has a DataRank of 0. It has been cited 7 times.

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Open Access7 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (9 grants)Impact (FWCI 0.55)OA: goldTopics (63)IDs (PubMed, PMC, OpenAlex)Annotations (2)SDGs (2)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (4)

Sarah Corum,Patrick Leahy,Anusha Bangalore,David Danielpour ORCID

Live enrichment

PubMed:35992379 PMC:PMC9389240 OpenAlex:https://openalex.org/W4283802633

Case Western Reserve University School of Medicine

Grant: BFA2014-004

National Cancer Institute

Grant: P30CA43703

National Cancer Institute

Grant: R01CA134878

NCI NIH HHS

Grant: P30 CA043703

National Institutes of Health

Grant: 3P30CA043703-20S1

Case Comprehensive Cancer Center Support Grant

National Institutes of Health

Grant: 5R01CA134878-05

Control of TGF-Beta/Smad Signaling by mTOR in Prostate Cancer

Case Western Reserve University

National Institutes of Health

Case Comprehensive Cancer Center, Case Western Reserve University

FWCI

0.55

Citation Percentile

0.6%

Citation Trend

2023

2025

goldLicense: cc-by-nc-nd

journalhttps://www.sciencedirect.com/science/article/pii/S2590257122000372/pdf

publisherhttps://www.sciencedirect.com/science/article/pii/S2590257122000372/pdf

publisherhttps://api.elsevier.com/content/article/PII:S2590257122000372?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S2590257122000372?httpAccept=text/plain

journalhttps://doi.org/10.1016/j.crphar.2022.100117

Fields of Study

PI3K/AKT/mTOR signaling in cancerDevelopmental Biology and Gene Regulation0301 basic medicine0303 health sciences03 medical and health sciences

Keywords

PI3K/AKT/mTOR pathwayJAG1Cancer researchProtein kinase BGene silencingNotch signaling pathwayClear cell renal cell carcinomaCell growthCancer cellChemistryCell biologyBiologySignal transductionCancerMedicineInternal medicineRenal cell carcinomaBiochemistrySmad4TGF-betaSlugRapamycinPI3KHic-5Renal CancerMtorEmtAKTBsa, Bovine Serum AlbuminFbs, Fetal Bovine SerumTgf-β, Transforming Growth Factor-betaEdta, Ethylenediaminetetraacetic AcidPi3k, Phosphatidylinositol 3-KinaseAnova, Analysis Of VarianceBez235Se, Standard ErrorRap, RapamycinIrs-1, Insulin Receptor Substrate-1Mtorc1, Mammalian Target Of Rapamycin Complex 1Tsc, Tuberous Sclerosis ComplexCcrcc, Clear Cell Renal Cell CarcinomaMrcc, Metastatic Renal Cell CarcinomaKu-0063794Mtorc2, Mammalian Target Of Rapamycin Complex 2Myr, MyristoylatedAlk5, Activin-like Kinase 5 (Tgf-β Type I Receptor)Hic-5, Hydrogen Peroxide-inducible Clone 5, Also Known As Transforming Growth Factor Beta Induced TranscriptJag1, Jagged-1Maml-1, Mastermind-like Protein-1Rcc, RccRheb, Ras Homologue Enriched In BrainSlug, Snail Family Of Transcription Factors Encoded By The Snai2 GeneSmad, Mothers Against Decapentaplegic HomologTβri, Transforming Growth Factor Β Receptor Type 1Tβrii, Transforming Growth Factor Β Receptor Type 2Therapeutics. PharmacologyRM1-950Research Article

Sustainable Development Goals

SDG 3: 3. Good healthSDG 0: Good health and well-being

Jagged-1 is induced by mTOR inhibitors in renal cancer cells through an Akt/ALK5/Smad4-dependent mechanism

FAIR Checklist

Authors (4)

Funding (9 grants)

Impact

Open Access

Topics

Annotations (Europe PMC)