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The modulation of transcriptional expression and inhibition of multidrug resistance associated protein 4 (MRP4) by analgesics and their primary metabolites

Current Research in Toxicology(2020)10.1016/j.crtox.2020.04.002Source: DataRank Database

The modulation of transcriptional expression and inhibition of multidrug resistance associated protein 4 (MRP4) by analgesics and their primary metabolites is a research paper published in Current Research in Toxicology (2020). On theSindex it has a DataRank of 0. It has been cited 2 times.

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0DataRank · unranked

Scored on demand from live citation data

Open Access2 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (3 grants)Impact (FWCI 0.08)OA: goldTopics (48)IDs (PubMed, PMC, OpenAlex)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (3)

Carolina I. Ghanem ORCID,José E. Manautou ORCID,Renato J. Scialis

Live enrichment

PubMed:34345835 PMC:PMC8320619 OpenAlex:https://openalex.org/W3023440205

National Institutes of Health

Grant: DK069557

NIDDK NIH HHS

Grant: R01 DK069557

National Institutes of Health

Grant: 1R01DK069557-01A1

Transporter Expression in Response to Hepatotoxicants

FWCI

0.08

Citation Percentile

0.4%

Citation Trend

2022

2026

goldLicense: cc-by-nc-nd

journalhttps://ars.els-cdn.com/content/image/1-s2.0-S2666027X20300050-ga1.jpg

GOLDhttps://ars.els-cdn.com/content/image/1-s2.0-S2666027X20300050-ga1.jpg

publisherhttps://ars.els-cdn.com/content/image/1-s2.0-S2666027X20300050-ga1.jpg

publisherhttps://api.elsevier.com/content/article/PII:S2666027X20300050?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S2666027X20300050?httpAccept=text/plain

Fields of Study

Drug Transport and Resistance MechanismsDrug-Induced Hepatotoxicity and ProtectionPharmacological Effects and Toxicity StudiesMedicineChemistry0301 basic medicine0303 health sciences03 medical and health sciences

Keywords

GlutathionePharmacologyAcetaminophenGCLCChemistryLiver injuryOxidative stressDownregulation and upregulationIn vivoEffluxBiochemistryBiologyEnzymeGeneInhibitionMetaboliteDiclofenacMrp4Atp, Adenosine TriphosphateIs, Internal StandardAlt, Alanine AminotransferaseApap, AcetaminophenPge2, Prostaglandin E2Amp, Adenosine MonophosphateMrp, Multidrug Resistance-associated ProteinLtc4, Leukotriene C4Apap-cys, Acetaminophen CysteineApap-glu, Acetaminophen GlucuronideApap-nac, Acetaminophen N-acetylcysteineApap-sul, Acetaminophen SulfateDcf, DiclofenacDcf-ag, Diclofenac Acyl GlucuronideFmo, Flavin Containing MonooxygenaseOh-dcf, 4′-Hydroxy DiclofenacArticlehttps://purl.org/becyt/ford/3.5ANALGESICRA1190-1270Toxicology. Poisonshttps://purl.org/becyt/ford/3

Sustainable Development Goals

SDG 0: Good health and well-being