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NPC1-mTORC1 Signaling Couples Cholesterol Sensing to Organelle Homeostasis and Is a Targetable Pathway in Niemann-Pick Type C

Developmental Cell(2020)10.1016/j.devcel.2020.11.016Source: DataRank Database

NPC1-mTORC1 Signaling Couples Cholesterol Sensing to Organelle Homeostasis and Is a Targetable Pathway in Niemann-Pick Type C is a research paper published in Developmental Cell (2020). On theSindex it has a DataRank of 0. It has been cited 202 times.

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Open Access202 citations

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datarank_citation_only_1hop_v6· scope data_onlyMethodology

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Enrichment:Funding (6 grants)Impact (FWCI 11.64)OA: greenTopics (74)IDs (PubMed, PMC, OpenAlex)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (9)

Hijai R. Shin ORCID,Chun-Yan Lim ORCID,Emma Wu,Matthew A. Kukurugya ORCID,Claire Maher ORCID

Live enrichment

PubMed:33308480 PMC:PMC8919971 OpenAlex:https://openalex.org/W3111564394

NCI NIH HHS

Grant: DP2 CA216364

NIGMS NIH HHS

Grant: R01 GM127763

NIGMS NIH HHS

Grant: R01 GM130995

National Institutes of Health

Grant: 1R01GM130995-01A1

Spatio-temporal regulation of mTORC1 signaling in normal and disease states

National Institutes of Health

Grant: 5R01GM127763-04

Molecular mechanisms for lipid sensing by mTORC1

National Institutes of Health

FWCI

11.64

Citation Percentile

1.0%

Citation Trend

2020

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2026

greenLicense: Elsevier Non-Commercial

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/8919971

publisherhttps://api.elsevier.com/content/article/PII:S1534580720309254?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S1534580720309254?httpAccept=text/plain

journalhttps://doi.org/10.1016/j.devcel.2020.11.016

Fields of Study

Lysosomal Storage Disorders ResearchCarbohydrate Chemistry and SynthesisCalcium signaling and nucleotide metabolism0301 basic medicine03 medical and health sciences0303 health sciences

MeSH Terms

Mechanistic Target of Rapamycin Complex 1Niemann-Pick C1 ProteinAdultAnimalsCells, CulturedCholesterolHomeostasisHumansIntracellular MembranesLysosomesMitochondriaModels, BiologicalNeuronsOrganellesSignal TransductionIntracellular Signaling Peptides and ProteinsMiceNiemann-Pick Disease, Type CInduced Pluripotent Stem CellsHEK293 CellsProteolysis

Keywords

BiologyNPC1mTORC1HomeostasisOrganelleCholesterolCell biologySignal transductionEndocrinologyInternal medicineEndosomePI3K/AKT/mTOR pathwayMitochondriaLysosomeProteolysisProteomicsAutophagyEscrtAdultCellsInduced Pluripotent Stem CellsMechanistic Target of Rapamycin Complex 1Type CMedical and Health SciencesModels, BiologicalMiceModelsNiemann-Pick C1 ProteinNiemann-Pick Disease2.1 Biological and endogenous factorsAnimalsHumansAetiologyMetabolic and endocrineCells, CulturedNeuronsOrganellesCulturedIntracellular Signaling Peptides and ProteinsNiemann-Pick Disease, Type CIntracellular MembranesBiological SciencesBiologicalHEK293 CellsBiochemistry and cell biologyLysosomesDevelopmental Biology