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Functional genetic screen identifies ITPR3/calcium/RELB axis as a driver of colorectal cancer metastatic liver colonization

Developmental Cell(2022)10.1016/j.devcel.2022.04.010Source: DataRank Database

Functional genetic screen identifies ITPR3/calcium/RELB axis as a driver of colorectal cancer metastatic liver colonization is a research paper published in Developmental Cell (2022). On theSindex it has a DataRank of 0. It has been cited 23 times.

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Scored on demand from live citation data

Open Access23 citations

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Linked data & code

cellosaurus rrid doi

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (25 grants)Impact (FWCI 2.04)OA: greenTopics (46)IDs (PubMed, PMC, OpenAlex)Annotations (3)SDGs (2)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (10)

Alexander Nguyen ORCID,Jia Min Loo ORCID,Norihiro Yamaguchi ORCID,Christina M. Kajba ORCID,Balaji Santhanam ORCID

Live enrichment

PubMed:35487218 PMC:PMC9446818 OpenAlex:https://openalex.org/W4224980471

Blank Family Foundation

Grant: R01-HG009065

Blank Family Foundation

Grant: R01-CA257153

Damon Runyon Cancer Research Foundation

Grant: DRG 121-20

National Institutes of Health

Grant: K08CA263304

National Institutes of Health

Grant: U54CA261701

National Institutes of Health

Grant: T32CA00927

National Center for Advancing Translational Sciences

Grant: UL1TR001866

National Institute of General Medical Sciences

Grant: T32GM07739

NCI NIH HHS

Grant: R01 CA257153

NHGRI NIH HHS

Grant: R01 HG009065

NCI NIH HHS

Grant: T32 CA009207

NIGMS NIH HHS

Grant: T32 GM007739

National Institutes of Health

Grant: 5K08CA263304-02

Defining the mechanism of inositol 1,4,5-triphosphate receptor-mediated metastatic liver colonization in colorectal cancer

National Institutes of Health

Grant: 5R01HG009065-02

Massively parallel mapping of all molecular interactions in a single tube

National Institutes of Health

Grant: 5UL1TR001866-07

Developing, Demonstrating, and Disseminating Innovative Programs to Achieve Translational Success

National Institutes of Health

Grant: 5R01CA257153-04

Mapping the regulatory landscape of RNA binding proteins and their causal roles in tumorigenesis and patient survival

National Institutes of Health

Grant: 1U54CA261701-01

Center for Systems-level Study of Metastasis

National Institutes of Health

Grant: 5T32GM007739-30

Weill Cornell/Rockefeller/Sloan-Kettering MST Program

Meyer Foundation

Howard Hughes Medical Institute

National Cancer Institute

Breast Cancer Research Foundation

Debra and Leon Black Family Foundation

Studienstiftung des Deutschen Volkes

Rockefeller University

FWCI

2.04

Citation Percentile

0.9%

Citation Trend

2022

2023

2024

2025

2026

greenLicense: Elsevier Non-Commercial

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/9446818

publisherhttps://api.elsevier.com/content/article/PII:S1534580722002507?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S1534580722002507?httpAccept=text/plain

journalhttps://doi.org/10.1016/j.devcel.2022.04.010

Fields of Study

Endoplasmic Reticulum Stress and DiseasePancreatic and Hepatic Oncology ResearchLiver Disease Diagnosis and Treatment0301 basic medicine03 medical and health sciences0303 health sciences

MeSH Terms

CalciumHumansLiver NeoplasmsColorectal NeoplasmsNF-kappa BTranscription Factor RelBInositol 1,4,5-Trisphosphate Receptors

Keywords

RELBBiologyColorectal cancerCancer researchColonizationCancerGeneTranscription factorGeneticsNFKB1MicrobiologyCalciumHypoxiaMetastasisNon-canonical Nf-κbItpr34Medical and Health SciencesHumansInositol 1,4,5-Trisphosphate Receptors5-Trisphosphate ReceptorsLiver DiseasePreventionLiver NeoplasmsTranscription Factor RelBNF-kappa BBiological SciencesInositol 1Colo-Rectal CancerBiochemistry and cell biologyDigestive DiseasesColorectal NeoplasmsDevelopmental Biology

Sustainable Development Goals

SDG 3: 3. Good healthSDG 0: Good health and well-being