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Structure-activity relationship of isoprenoid triazole bisphosphonate-based geranylgeranyl diphosphate synthase inhibitors: Effects on pharmacokinetics, biodistribution, and hepatic transporters

Drug Metabolism and Disposition(2025)10.1016/j.dmd.2025.100038Source: DataRank Database

Structure-activity relationship of isoprenoid triazole bisphosphonate-based geranylgeranyl diphosphate synthase inhibitors: Effects on pharmacokinetics, biodistribution, and hepatic transporters is a research paper published in Drug Metabolism and Disposition (2025). On theSindex it has a DataRank of 0. It has been cited 3 times.

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Open Access3 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (3 grants)Impact (FWCI 2.27)OA: greenTopics (44)IDs (PubMed, PMC, OpenAlex)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (5)

Yashpal S. Chhonker ORCID,Mamunur Rashid ORCID,Daryl J. Murry ORCID,Sarah A. Holstein ORCID,Staci L. Haney ORCID

Live enrichment

PubMed:40024136 PMC:PMC12105759 OpenAlex:https://openalex.org/W4406606598

National Cancer Institute

Grant: P30CA036727

National Cancer Institute

Grant: R01CA258621

National Institutes of Health

FWCI

2.27

Citation Percentile

0.9%

Citation Trend

2025

2026

greenLicense: cc-by-nc-nd

repositoryhttps://pmc.ncbi.nlm.nih.gov/articles/PMC12105759/pdf/main.pdf

publisherhttps://api.elsevier.com/content/article/PII:S0090955625075038?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S0090955625075038?httpAccept=text/plain

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/12105759

Fields of Study

HIV/AIDS drug development and treatmentProtein Degradation and InhibitorsUbiquitin and proteasome pathwaysAnimalsLiverStructure-Activity RelationshipFarnesyltranstransferaseTissue DistributionTerpenesDiphosphonatesTriazolesMaleEnzyme InhibitorsHumansMiceMembrane Transport Proteins

MeSH Terms

AnimalsDiphosphonatesEnzyme InhibitorsHumansLiverMaleStructure-Activity RelationshipTerpenesTissue DistributionTriazolesMembrane Transport ProteinsFarnesyltranstransferaseMice

Keywords

Farnesyl diphosphate synthaseChemistryCytochrome P450BiodistributionBiochemistryPharmacologyTransporterATP synthaseEnzymeBiologyIn vitroGeneStructure-functionGeranylgeranyl diphosphate synthaseHepatic Uptake

Sustainable Development Goals

SDG 0: Clean water and sanitation