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Impact of variation in CYP3A and CYP2C8 on tucatinib metabolic clearance in human liver microsomes

Drug Metabolism and Disposition(2025)10.1016/j.dmd.2025.100061Source: DataRank Database

Impact of variation in CYP3A and CYP2C8 on tucatinib metabolic clearance in human liver microsomes is a research paper published in Drug Metabolism and Disposition (2025). On theSindex it has a DataRank of 0. It has been cited 3 times.

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Scored on demand from live citation data

Open Access3 citations

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Enrichment:Funding (7 grants)Impact (FWCI 2.56)OA: greenTopics (25)IDs (PubMed, PMC, OpenAlex)Annotations (2)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (5)

Pegah Montazeri,Licza F. Lobo,John K. Fallon ORCID,Klarissa D. Jackson ORCID,Bethany D. Latham ORCID

Live enrichment

PubMed:40233610 PMC:PMC13095627 OpenAlex:https://openalex.org/W4408288043

National Center for Research Resources

Grant: S10RR024595

NIH National Institute of General Medical Sciences

Grant: R35GM143044

National Institutes of Health

Genentech Foundation

University of North Carolina

Genentech

Pfizer

FWCI

2.56

Citation Percentile

0.9%

Citation Trend

2025

2026

greenLicense: http://www.elsevier.com/open-access/userlicense/1.0/

repositoryhttps://pmc.ncbi.nlm.nih.gov/articles/PMC13095627/

publisherhttps://api.elsevier.com/content/article/PII:S0090955625090701?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S0090955625090701?httpAccept=text/plain

journalhttps://doi.org/10.1016/j.dmd.2025.100061

Fields of Study

Pharmacogenetics and Drug MetabolismDrug Transport and Resistance MechanismsCancer, Hypoxia, and Metabolism

MeSH Terms

AdultFemaleHumansMaleMetabolic Clearance RateMicrosomes, LiverMiddle AgedPyridinesQuinazolinesCytochrome P-450 CYP3ATandem Mass SpectrometryCytochrome P-450 CYP2C8

Keywords

CYP3AMicrosomeMicrosomaBiologyChemistryBiochemistryIn vitroCytochrome p450Kinase InhibitorInterindividual Variability

Sustainable Development Goals

SDG 0: Zero hunger

Impact of variation in CYP3A and CYP2C8 on tucatinib metabolic clearance in human liver microsomes

FAIR Checklist

Authors (5)

Funding (7 grants)

Impact

Open Access

Topics

Annotations (Europe PMC)