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The strong clinical interaction between bupropion and CYP2D6 is primarily mediated through bupropion metabolites and their stereoisomers: A paradigm for evaluating metabolites in drug-drug interaction risk

Drug Metabolism and Disposition(2025)10.1016/j.dmd.2025.100070Source: DataRank Database

The strong clinical interaction between bupropion and CYP2D6 is primarily mediated through bupropion metabolites and their stereoisomers: A paradigm for evaluating metabolites in drug-drug interaction risk is a research paper published in Drug Metabolism and Disposition (2025). On theSindex it has a DataRank of 0. It has been cited 1 time.

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Enrichment:Funding (5 grants)OA: greenTopics (14)IDs (PubMed, PMC)Annotations (1)

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Authors (5)

Amir Rashidian ORCID,Brandon T. Gufford ORCID,Jessica Bo Li Lu ORCID,Zeruesenay Desta ORCID,Irin Tanaudommongkon

Live enrichment

PubMed:40245579 PMC:PMC13095643

National Institute of General Medical Sciences

Grant: R35 GM145383

National Institute of General Medical Sciences

Grant: RO1 GM121707

National Institute of General Medical Sciences

Grant: T32GM008425

NIGMS NIH HHS

Grant: R01 GM121707

National Institutes of Health

greenLicense: https://www.elsevier.com/legal/tdmrep-license

repositoryhttps://pmc.ncbi.nlm.nih.gov/articles/PMC13095643/

publisherhttps://api.elsevier.com/content/article/PII:S0090955625090798?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S0090955625090798?httpAccept=text/plain

MeSH Terms

Microsomes, LiverHumansBupropionDextromethorphanCytochrome P-450 CYP2D6Drug InteractionsStereoisomerismCytochrome P-450 CYP2D6 Inhibitors

Keywords

InhibitionCYP2D6bupropionDrug-drug InteractionPredictionsCirculating Metabolites

The strong clinical interaction between bupropion and CYP2D6 is primarily mediated through bupropion metabolites and their stereoisomers: A paradigm for evaluating metabolites in drug-drug interaction risk

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Authors (5)

Funding (5 grants)

Open Access

Topics

Annotations (Europe PMC)