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Pharmacodynamic determinants of mitochondrial one-carbon flux and serine hydroxymethyltransferase inhibition in human tumors

Drug Metabolism and Disposition(2025)10.1016/j.dmd.2025.100120Source: DataRank Database

Pharmacodynamic determinants of mitochondrial one-carbon flux and serine hydroxymethyltransferase inhibition in human tumors is a research paper published in Drug Metabolism and Disposition (2025). On theSindex it has a DataRank of 0. It has been cited 2 times.

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0DataRank · unranked

Scored on demand from live citation data

Open Access2 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (8 grants)Impact (FWCI 1.07)OA: greenTopics (33)IDs (PubMed, OpenAlex)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (12)

Carrie O’Connor,Xun Bao ORCID,Md. Junayed Nayeen ORCID,Tejashree Magdum ORCID,Abhishekh Sharma

Live enrichment

PubMed:40816224 OpenAlex:https://openalex.org/W4413075713

National Institutes of Health National Cancer Institute

Grant: P30CA22453

National Institutes of Health National Cancer Institute

Grant: R01 CA53535

National Institutes of Health National Cancer Institute

Grant: T32 CA009531

NCI NIH HHS

Grant: R01 CA053535

NCI NIH HHS

Grant: R01 CA250469

Cancer Research Institute

National Institutes of Health

Duquesne University

FWCI

1.07

Citation Percentile

0.8%

Citation Trend

2026

greenLicense: http://www.elsevier.com/open-access/userlicense/1.0/

repositoryhttps://pmc.ncbi.nlm.nih.gov/articles/PMC13169307/

publisherhttps://api.elsevier.com/content/article/PII:S0090955625091299?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S0090955625091299?httpAccept=text/plain

journalhttps://doi.org/10.1016/j.dmd.2025.100120

Fields of Study

Amino Acid Enzymes and MetabolismCancer, Hypoxia, and MetabolismMetabolism and Genetic DisordersMedicine

MeSH Terms

CarbonCytosolFolic AcidFolic Acid AntagonistsHeLa CellsHumansMitochondriaNeoplasmsPeptide SynthasesGlycine HydroxymethyltransferaseReduced Folate Carrier ProteinProton-Coupled Folate TransporterHela Cells

Keywords

Serine hydroxymethyltransferaseFlux (metallurgy)PharmacodynamicsSerineBiologyPharmacologyChemistryPharmacokineticsBiochemistryEnzymeReduced Folate CarrierOne-carbon MetabolismAntifolateProton-coupled Folate TransporterFolylpolyglutamate SynthetaseSerine Hydroxymethyltransferase 2