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Mechanistic insights into human carboxylesterase 2 (CES2) inhibition by the CES1 prodrug substrate remdesivir

Drug Metabolism and Disposition(2025)10.1016/j.dmd.2025.100158Source: DataRank Database

Mechanistic insights into human carboxylesterase 2 (CES2) inhibition by the CES1 prodrug substrate remdesivir is a research paper published in Drug Metabolism and Disposition (2025). On theSindex it has a DataRank of 0. It has been cited 3 times.

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Open Access3 citations

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datarank_citation_only_1hop_v6· scope data_onlyMethodology

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Enrichment:Funding (4 grants)Impact (FWCI 2.23)OA: greenTopics (30)IDs (PubMed, PMC, OpenAlex)Annotations (2)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (3)

Sylvie E. Kandel ORCID,Jed N. Lampe ORCID,Abhinav Pentyala

Live enrichment

PubMed:41061301 PMC:PMC13095431 OpenAlex:https://openalex.org/W4414147182

National Institute of Allergy and Infectious Diseases

Grant: AI183687

National Institute of Allergy and Infectious Diseases

Grant: AI176245

NIAID NIH HHS

Grant: R01 AI183687

National Institutes of Health

FWCI

2.23

Citation Percentile

0.9%

Citation Trend

2026

greenLicense: cc-by-nc-nd

repositoryhttps://pmc.ncbi.nlm.nih.gov/articles/PMC13095431/

publisherhttps://api.elsevier.com/content/article/PII:S0090955625091676?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S0090955625091676?httpAccept=text/plain

journalhttps://doi.org/10.1016/j.dmd.2025.100158

Fields of Study

Computational Drug Discovery MethodsCholinesterase and Neurodegenerative DiseasesPharmacogenetics and Drug Metabolism

MeSH Terms

COVID-19SARS-CoV-2COVID-19 Drug TreatmentAdenosine MonophosphateAlanineAntiviral AgentsCarboxylic Ester HydrolasesCytidineHumansHydrolysisHydroxylaminesProdrugsCarboxylesteraseMolecular Docking Simulation

Keywords

CarboxylesteraseProdrugMechanism of actionIn silicoDrugEnzymeRecombinant DNASerine hydrolaseCarboxylesterasesTime-dependent InhibitionRemdesivirCovid-19 Antiviral DrugsBimolecular Inactivation Rate Constant

Mechanistic insights into human carboxylesterase 2 (CES2) inhibition by the CES1 prodrug substrate remdesivir

FAIR Checklist

Authors (3)

Funding (4 grants)

Impact

Open Access

Topics

Annotations (Europe PMC)