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N-acetyltransferase (NAT) 1 and NAT2 enzyme activities drive interindividual variability in sulfamethoxazole N-acetylation

Drug Metabolism and Disposition(2025)10.1016/j.dmd.2025.100195Source: DataRank Database

N-acetyltransferase (NAT) 1 and NAT2 enzyme activities drive interindividual variability in sulfamethoxazole N-acetylation is a research paper published in Drug Metabolism and Disposition (2025). On theSindex it has a DataRank of 0. It has been cited 1 time.

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Open Access1 citations

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Enrichment:Funding (4 grants)Impact (FWCI 0.88)OA: greenTopics (27)IDs (PubMed, PMC, OpenAlex)Annotations (3)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (8)

Bethany D. Latham ORCID,Amanda J. Gerringer ORCID,Tyler Interrante ORCID,Corbin D. Jones ORCID,Tristan De Buysscher

Live enrichment

PubMed:41344065 PMC:PMC12861138 OpenAlex:https://openalex.org/W4415766961

National Institute of General Medical Sciences

Grant: R35GM143044

National Institutes of Health

Grant: S10OD032350

University of North Carolina

The University of North Carolina at Chapel Hill School of Medicine

FWCI

0.88

Citation Percentile

0.8%

Citation Trend

2026

greenLicense: http://www.elsevier.com/open-access/userlicense/1.0/

repositoryhttps://pmc.ncbi.nlm.nih.gov/articles/PMC12861138/

publisherhttps://api.elsevier.com/content/article/PII:S0090955625095042?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S0090955625095042?httpAccept=text/plain

journalhttps://doi.org/10.1016/j.dmd.2025.100195

Fields of Study

Drug-Induced Hepatotoxicity and ProtectionPharmacogenetics and Drug MetabolismPneumocystis jirovecii pneumonia detection and treatment

MeSH Terms

AcetylationAdultArylamine N-AcetyltransferaseFemaleGenotypeHumansIsoenzymesMaleMicrosomes, LiverMiddle AgedSulfamethoxazoleHepatocytes

Keywords

MetaboliteCytochrome P450MetabolismSulfamethoxazoleEnzymePhenotypeIsozymeDrug metabolismN-acetyltransferaseTargeted ProteomicsDrug-induced Liver InjuryInterindividual Variability

N-acetyltransferase (NAT) 1 and NAT2 enzyme activities drive interindividual variability in sulfamethoxazole N-acetylation

FAIR Checklist

Authors (8)

Funding (4 grants)

Impact

Open Access

Topics

Annotations (Europe PMC)